右美托咪啶对重症治疗室患者镇静效果研究

目的观察盐酸右美托咪啶对重症治疗室患者的镇静效果及安全性。方法将50例重症创伤而需要机械通气的ICU患者随机分为两组；A咪达唑仑组（n=25）和B盐酸右美托咪啶组（n=25）。记录镇静前的APACHEⅡ评分、Ramsay评分。分别观察镇静中4、8、12h的心率，平均动脉血压，呼吸频率，氧饱和度等基本生命体征及用药后两药起效时间，恢复时间，镇静满意度，Ramsay评分和谵妄发生率等。结果B组血压、心率有明显下降但停药后马上恢复，而对呼吸氧饱和度影响均小于A组，安全性良好；且比较单纯咪达唑仑用量、调整泵速至镇静满意时间、镇静满意程度、恢复时间等，B组均明显少于A组（P〈0．05）。结论右美托咪啶用于重症治疗室患者镇静安全性好，能够提供良好的镇静。

The sedative effect research of dexmedetomidine in the ICU patients

Objective To observe the sedative effect of dexmedetomidine used for the ICU patients,and explore the different in safety and other aspects.Methods Fifty patients with severe trauma in ICU requiring mechanical ventilation were randomly divided into 2 groups;A midazolam group (n=25) and B dexmedetomidine group (n=25).Recorded the APACHEⅡ score and Ramsay score before sedation.Then severally observe and record heart rate,blood mean arterial pressure,respiratory rate,the oxygen saturation,and other basic vital signs at 4,6 and 12 hours after administration and the two drugs’ onset time,recovery time,sedation satisfaction,Ramsay score,and the incidence of delirium,etc.Results The blood pressure,and heart rate decreased significantly but soon recovered after treatment in the group B,while the oxygen saturation on the respiratory effects were less than in group A,so group B had good security;and compared to the amount of midazolam alone,adjusting pump speed to the sedation time satisfaction,satisfaction with sedation,recovery time,group B were significantly less than group A (P< 0.05).Conclusion Dexmedetomidine sedation for the intensive care unit patient is safe,and can provide good sedation.