| 周围型肺癌螺旋CT征象与VEGF表达的相关性研究 |
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| 引用本文： | 郭华,岳松伟,高剑波,杨学华,周志刚,吴逸明.周围型肺癌螺旋CT征象与VEGF表达的相关性研究[J].中国医学影像技术,2008,24(9):1427-1430. |
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| 作者姓名： | 郭华 岳松伟 高剑波 杨学华 周志刚 吴逸明 |
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| 作者单位： | 1. 郑州大学第一附属医院放射科,河南,郑州,450052
2. 郑州大学公共卫生学院,河南,郑州,450052 |
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| 摘 要： | 目的 探讨周围型肺癌螺旋CT征象与血管内皮生长因子(VEGF)表达间的关系.方法 对58例经手术或穿刺病理证实的周围型肺癌患者行螺旋CT扫描,手术或穿刺标本采用免疫组织化学SP法检测肿瘤组织中VEGF蛋白表达,将螺旋CT征象与VEGF表达进行对照.结果 螺旋CT判断胸膜侵犯准确率为86.67%,淋巴结转移准确率为88.24%,TNM分期的准确率为81.25%.VEGF的阳性表达率为63.34%,与病理分级显著相关(P＜0.05),而与病理类型无关(P＞0.05).VEGF的表达与周围型肺癌的毛刺征、棘突征、血管集束征、空洞征、胸膜侵犯和淋巴转移明显相关(P＜0.05),还与周围型肺癌的强化程度密切相关(P=0.035,r=0.533).结论 螺旋CT可清晰显示周围型肺癌的各种征象,较准确地反映肿瘤浸润转移的病理学和生物学特性,从而指导临床选择适当的治疗方案和对预后的判断.
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| 关 键 词： | 肺肿瘤 VEGF体层摄影术 X线计算机 |
| 收稿时间： | 1/4/2008 12:00:00 AM |
| 修稿时间： | 2008/3/10 0:00:00 |
Correlation between spiral CT features and expression of VEGF in peripheral pulmonary carcinoma |
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| GUO Hu,YUE Song-wei,GAO Jian-bo,YANG Xue-hu,ZHOU Zhi-gang and WU Yi-ming.Correlation between spiral CT features and expression of VEGF in peripheral pulmonary carcinoma[J].Chinese Journal of Medical Imaging Technology,2008,24(9):1427-1430. |
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| Authors: | GUO Hu YUE Song-wei GAO Jian-bo YANG Xue-hu ZHOU Zhi-gang and WU Yi-ming |
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| Affiliation: | Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Public Health of Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | |
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| Keywords: | Lung neoplasms VEGF Tomography X-ray computed |
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