不同置换液量单次血液透析滤过治疗对血透患者血磷及甲状旁腺素的影响

目的观察不同置换液量单次血液透析滤过（HDF）治疗对血透患者血磷（P）及甲状旁腺素（PTH）的清除效果。方法间断行HDF治疗血透患者40例分成A、B两组，A组接受高置换液量后稀释HDF（置换液量20L），B组接受低置换液量后稀释HDF（置换液量10L），比较两组病人单次HDF治疗前后血P和PTH浓度的变化。结果两组病人行HDF后血P、PTH均有明显下降（P〈0．05），A组对血P及PTH清除率分别为（40．30±6．81）％和（53．02±3．06）％；B组对血P及PTH清除率为（28．12±6．45）％和（32．17±2．05）％；A组清除效果更明显（P〈0．05），差异有显著性。结论HDF能有效清除血透患者血P及PTH，增加置换液量可以提高其清除效果。

Influence on single hemodiafiltration therapy with different amount of substitute fluid on the phosphorus and parathyroid hormone in hemodialysis patients

Objective To observe the clearance effect of single hemodiafiltration(HDF) therapy with different amount of substitute fluid on the phosphorus(P) and parathyroid hormone(PTH) in hemodialysis patients.Methods 40 cases of hemodialysis patients with HDF treatment intermittently were randomly divided into group A and B,group A received high volume of substitute fluid post-dilution HDF (substitute fluid 20 L),group B received low volume post-dilution HDF (substitute fluid 10 L).The concentration changes on the P and PTH before and after the single HDF treatment in the two groups were compared.Results The serum P,PTH were significantly reduced (P ＜ 0.05) after HDF for two groups,the clearance rates for P and PTH were (40.30 ± 6.81)％ and (53.02 ± 3.06)％ in group A,the clearance rates for P and PTH were (28.12 ± 6.45)％ and (32.17 ± 2.05)％ respectivdy; the clearance effect was more effective in group A(P＜ 0.05)and the difference was statistically significant.Conclusion HDF can effectively clear P and PTH in hemodialysis patients,increasing the amount of substitute fluid can improve the clearance effect.