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| 肾衰宁对糖尿病大鼠肾脏损伤的保护作用 | |
| 引用本文： | 范例,高洁,刘茂静,甄军晖,姜虹,胡昭. 肾衰宁对糖尿病大鼠肾脏损伤的保护作用[J]. 山东大学学报(医学版), 2011, 49(1): 48-52 |
| 作者姓名： | 范例 高洁 刘茂静 甄军晖 姜虹 胡昭 |
| 作者单位： | 1. 山东大学齐鲁医院,肾内科,济南,250012 2. 山东大学齐鲁医院,病理科,济南,250012 3. 山东大学齐鲁医院教育部和卫生部心血管重构与功能研究重点实验室,济南,250012 |
| 基金项目： | 国家科技支撑计划资助项目（２００７ＢＡＩ０４Ｂ１０）。 |
| 摘 要： | 目的 探讨肾衰宁对糖尿病大鼠肾脏的保护作用及可能机制.方法 雄性Vista大鼠24只,随机选取8只作为正常对照组(N组),其余16只注射链脲佐茵素(STZ)制成糖尿病模型,并随机分为糖尿病肾病组(DN组,n=8)和肾衰宁治疗组(S组,n=8),给药8周.检测血糖、肾功能、24 h尿蛋白定量等指标,并进行肾脏病理学检查及... |
| 关 键 词： | 糖尿病,肾性 肾衰宁 转化生长因子β1 层黏连蛋白 Ⅳ型胶原蛋白 |
| 收稿时间： | 2010-08-05 |
Protective effect of Shenshuaining on kidney injury in diabetic rats |
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| FAN Li,GAO Jie,LIU Mao-jing,ZHEN Jun-hui,JIANG Hong,HU Zhao. Protective effect of Shenshuaining on kidney injury in diabetic rats[J]. Journal of Shandong University:Health Sciences, 2011, 49(1): 48-52 | |
| Authors: | FAN Li GAO Jie LIU Mao-jing ZHEN Jun-hui JIANG Hong HU Zhao |
| Affiliation: | QiLu Hospital of ShanDong University 1. Department of Nephrology, 2. Department of Pathology, 3. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China |
| Abstract: | Objective To investigate the protective effect and mechanism of Shenshuaining on kidney injury in diabetic rats.Methods Of 24 male vista rats,8 rats were randomly selected as the control group(N group),while the other 16 rats were induced into the diabetic models by a single intraperitoneal streptozotocia(STZ) injection.Then,the latter group was randomly divided into the diabetic nephropathy group(DN group,n =8) and the Shenshuaining treating group(S group,n =8).The therapy lasted for 8 weeks.Blood glucose,... |
| Keywords: | Diabetes, renal Shenshuaining Transforming growth factor-beta l Laminin Collagen IV |
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