非高密度脂蛋白胆固醇及基质金属蛋白酶3对老年高血压患者急性冠脉综合征发生的影响

目的研究血清非高密度脂蛋白胆固醇(non-HDL-C)及基质金属蛋白酶3 (MMP3)对老年高血压患者急性冠脉综合征(ACS)发病的影响。方法 2016年1月一2017年12月,收集60岁以上高血压患者住院当天生化检测样本,检测MMP3、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1 (Apo A1)、载脂蛋白B (Apo B)及脂蛋白a Lp (a)]水平。并根据是否发生ACS,将患者分为ACS组和非ACS组,分析non-HDL-C和MMP3水平对ACS发病的影响。结果 391例患者年龄60~105岁,平均(75.8±11.7)岁,其中ACS组179例、非ACS组212例。ACS组患者年龄大于非ACS组(P=0.000);男性患者占比及合并糖尿病者多于非ACS组。Logistic回归分析发现,年龄、性别、TG、non-HDL-C、MMP3、是否糖尿病及低HDL-C是ACS发病的独立危险因素。Logistic逐步回归分析发现,高龄(OR=1.030,P=0.008)、non-HDL-C升高(OR=0.342,P=0.006)、MMP3 升高(OR=1.003,P=0.049)及糖尿病患者(OR=2.094,P<0.001) ACS 发生风险大。结论 non-HDL-C 和 MMP3可能是影响老年高血压患者ACS发病的危险因素。

The effect of non-high density lipoprotein cholesterol and matrix metalloproteinase 3 on the occurrence of acute coronary syndrome in elderly patients with hypertension

Objective To investigate the effect of serum non-high density lipoprotein cholesterol(non-HDL-C) and matrix metalloproteinases 3(MMP3) on the occurrence of acute coronary syndrome(ACS) in elderly patients with hypertension.Methods From January 2016 to December 2017,the serum samples of hypertensive patients over 60 years old on the day of hospitalization were collected to detect the levels of serum MMP3,total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(Apo A1),apolipoprotein B(Apo B) and lipoprotein a Lp(a)].According to whether ACS occurs,the patients were divided into ACS group and nonACS group,and the effects of non-HDL-C and MMP3 levels on the occurrence of ACS were analyzed.ResultsA total of 391 patients were collected,aged 60 to 105 years old,with an average of(75.8±11.7) years old,including 179 cases in the ACS group and 212 ones in the non-ACS group.Proportions of male patients and diabetic patients in ACS group were higher than those in non-ACS group.Logistic regression analysis showed that age,gender,TG,non-HDL-C,MMP3,diabetes mellitus and low HDL-C were independent risk factors for the occurrence of ACS.Logistic stepwise regression analysis showed that the patients with advanced age(OR=1.030,P=0.008),high non-HDL-C(OR=0.342,P=0.006),high MMP3(OR=1.003,P=0.049)and diabetes mellitus(OR=2.094,P<0.001) had the greater risk of ACS.ConclusionNon-HDL-C and MMP3 may be risk factors for ACS in elderly patients with hypertension.