东莞市厚街镇健康体检者高尿酸血症发生情况及危险因素分析

目的了解东莞市厚街镇健康体检者血清尿酸(SUA)水平、高尿酸血症(HUA)发生率及其危险因素,为防治HUA提供参考。方法对2018年9月至2019年12月该院2645例健康体检者的生化指标进行统计分析。根据SUA水平将所有研究对象分为HUA组与非HUA组,比较两组各项生化指标水平。结果2645例健康体检者SUA水平为(368±97)μmol/L,HUA发生率为32.36%(856/2645),男性SUA水平及HUA发生率均明显高于女性,差异有统计学意义(P<0.001)。≥60岁男性、女性HUA发生率比较,差异无统计学意义(P=0.198),其余各年龄段不同性别健康体检者间SUA水平和HUA发生率比较,差异有统计学意义(P<0.001)。HUA组与非HUA组的肌酐(Crea)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异均有统计学意义(P<0.001)。Crea、TG、LDL-C是HUA的危险因素,HDL-C则是HUA的保护因素。结论厚街镇健康体检者的HUA发生率较高,尤其是男性和≥60岁的女性,Crea、TG、LDL-C是HUA的危险因素,HDL-C则是HUA的保护因素。

Analysis on prevalence and risk factors of hyperuricemia in health examiner in Houje town of Dongguan city

Objective To analyze the level of serum uric acid(SUA)and the prevalence of hyperuricemia(HUA)and its risk factors in Houjie town of Dongguan city,to provide reference for prevention and diagnosis of HUA.Methods The biochemical indexes of 2645 people who participated in the health examination in Dongguan Renkang Hospital from September 2018 to December 2019 were analyzed statistically.According to the SUA level,all the subjects were divided into HUA group and non-HUA group,and then compared the biochemical indexes of the two groups.Results The level of SUA was(368±97)μmol/L in 2645 people,and the incidence rate of HUA was 32.36%(856/2645).The level of SUA and the incidence rate of HUA in males were significantly higher than those in females(P<0.001).There was no significant difference(P=0.198)on the incidence rate of HUA between males and females with≥60 years old,and there were significant differences on the incidence rate of HUA and the level of SUA between males and females in the other age groups(P<0.001).The creatinine(Crea),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)levels of HUA group and non-HUA group were significant different(P<0.001).Crea,TG and LDL-C were risk factors for HUA,while HDL-C was protective factor for HUA.Conclusion The incidence rate of HUA is relatively high in Houjie town,especially in all males and females with≥60 years old.Crea,TG,LDL-C are risk factors for HUA,while HDL-C is protective factor for HUA.