Detection of early right ventricular dysfunction in Chagas' disease using Doppler tissue imaging |
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| Affiliation: | 1. Department of Internal Medicine, Creighton University School of Medicine, Omaha, NE, USA;2. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA;3. Division of Cardiovascular Diseases, University Hospitals Case Medical Center, Cleveland, OH, USA;4. Department of Internal Medicine, Boston University Medical Center, Boston, MA, USA;5. Sri Venkateshwaraa Medical College Hospital and Research Center, Puducherry, India;6. Department of Internal Medicine, Saint Peters University Hospital, New Brunswick, NJ, USA;7. Department of Cardiology, The Everett Clinic, Everett, WA, USA;8. Department of Cardiology, University of Miami Miller School of Medicine, Miami, FL, USA;1. Department of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100277, Gainesville, FL, 32610, USA;2. North Florida/South Georgia Veterans Health Systems, 1601 SW Archer Road, Gainesville, FL 32608, USA;1. Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 70000, Viet Nam;2. University of Medicine and Pharmacy, Ho Chi Minh City, 70000, Viet Nam;3. Faculty of Medicine, Minia University, Minia 61519, Egypt;4. Faculty of Medicine, Alexandria University, Beheira 22762, Egypt;5. Faculty of Medicine, Cairo University, Cairo 13719, Egypt;6. Faculty of Medicine, Sohag University, Sohag 82738, Egypt;7. Faculty of Medicine, Gezira University, 20, Wad Madani, Sudan;8. Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan;9. Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;10. Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan;1. Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany;2. German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany;3. University of Leipzig – Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany |
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| Abstract: | Background: The involvement of the right ventricle (RV) in Chagas' disease is frequent. Although echocardiography plays an important role in noninvasive assessment of cardiac function, evaluation of RV is challenging because of the anatomic and functional complexity of this chamber. Methods: To study early functional abnormalities in the RV, we selected 18 patients with Chagas' disease, no other disease, and a normal echocardiogram; and 12 normal individuals as a control group. All participants were submitted to Doppler tissue imaging and the parameters of systolic (systolic wave and regional isovolumic contraction time) and diastolic (early and late expansion waves) function were analyzed at the level of the interventricular septum and free wall of the RV. Results: Regional isovolumic contraction time values showed a statistically significant difference between the 2 groups both in the RV free (P = .0003) and septal (P = .003) walls. With respect to diastolic function, we observed a significant difference between groups involving the early expansion wave (P = .014) and e/a ratio (P = .004) of the RV free wall. Conclusion: Doppler tissue imaging proved to be useful in early detection of RV dysfunction in Chagas' disease, with potential use in risk stratification of these patients. (J Am Soc Echocardiogr 2002;15:1197-1201.) |
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