尖锐湿疣复发患者的细胞因子及淋巴细胞亚群的变化规律研究

目的探讨尖锐湿疣复发患者的细胞因子及免疫功能的变化规律。方法选取我院皮肤科收治的87例尖锐湿疣患者。将患者分为初发组与复发组。初发组48例,复发组39例,选取同期体检的42名健康者作为对照组。对3组人员的血清细胞因子IL-2、IL-4、IL-6及外周血T淋巴细胞亚群CD4+、CD8+、CD4+/CD8+分布水平进行检测及统计分析。结果 3组患者的IL-2、IL-4、IL-6、CD4+细胞、CD8+细胞、CD4+/CD8+水平之间比较差异均具有显著性(P0.05)。两两比较后发现,复发组患者的血清IL-2、IL-6、CD4+细胞、CD4+/CD8+水平均显著低于初发组与对照组(P0.05),血清IL-4、CD8+细胞水平均显著高于初发组与对照组(P0.05);初发组患者的血清IL-2、IL-4、IL-6、CD4+细胞、CD8+细胞、CD4+/CD8+水平与对照组比较差异均无显著性(P0.05)。结论尖锐湿疣复发患者存细胞免疫功能的失衡,细胞免疫功能低下可能是导致其反复发作的一个原因。

Study on the changes of cytokines and lymphocyte subsets in recurrent patients with condyloma acuminatum

Objective To investigate the changes of cytokines and immune function in patients with recurrent condyloma acuminatum. Methods A total of 87 patients with condyloma acuminatum were included in this study, and were assigned to two groups, primary group（n=48）, recurrent groups （n=39）. Another 42 healthy subjects were selected as controls （control group）. The peripheral bloodlevels of CD4+ T?lymphocyte, CD8+ T?lymphocyte, CD4+/CD8+ ratio and the levels of IL-2, IL?4, IL?6 were detected and analyzed statistically. Results There were significant differences in the levels of IL ?2, IL?4, IL?6, CD4+ T?lymphocyte, CD8+?T lymphocyte, CD4+/CD8+ ratio between the three groups（all P values were less than 0.05）. Serum IL?2, IL?6, CD4+/CD8+ ratio in the patients with relapse were sig-nificantly lower than those in the control group（all P values were less than 0.05）. There was no signifi-cant difference in serum IL?2, IL?4, IL?6, CD4+,CD8+,CD4+/CD8+ levels between the initial group and the control group（all P values were more than 0.05）. Conclusion In patients with recurrent condylo-ma acuminatum, there is an imbalance of cellular immune function, and this cellular immune dysfunc-tion may be a cause of recurrent attacks