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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Authors:Yunfan Sun  Liang Wu  Yu Zhong  Kaiqian Zhou  Yong Hou  Zifei Wang  Zefan Zhang  Jiarui Xie  Chunqing Wang  Dandan Chen  Yaling Huang  Xiaochan Wei  Yinghong Shi  Zhikun Zhao  Yuehua Li  Ziwei Guo  Qichao Yu  Liqin Xu  Jia Fan
Affiliation:1. Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China;2. BGI-Shenzhen, Beishan Industrial Zone, Shenzhen 518083, China;3. Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai 200032, China;4. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China;5. School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China;6. Shenzhen Key Laboratory of Single-Cell Omics, BGI-Shenzhen, Shenzhen 518100, China;7. Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;8. Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen 518120, China;9. Institute for Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing 100101, China;10. Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China;11. James D. Watson Institute of Genome Science, Hangzhou 310008, China;12. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute Rockville, MD 20850, USA;13. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Abstract:
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  • Keywords:single-cell RNA sequencing  hepatocellular carcinoma  early-relapse tumor  tumor ecosystem  immune microenvironment  immune therapy
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