注射用丹参多酚酸盐联合丙戊酸钠治疗脑卒中后癫痫患者的疗效分析

目的:研究注射用丹参多酚酸盐联合丙戊酸钠对脑卒中后癫痫的临床疗效和安全性。方法:选择2016年1月～2019年4月东南大学附属中大医院江北院区神经内科住院的80例脑卒中后癫痫患者,将其随机分为两组。对照组的40例患者仅给予丙戊酸钠治疗,观察组的40例患者给予丹参多酚酸盐联合丙戊酸钠治疗。比较两组治疗后的脑电图检查结果、癫痫症状控制情况。结果:治疗后,观察组总有效率为明显高于对照组(97.50%vs. 80%,P0.05);两组的累及导联数、痫样放电、发作持续时间、发作次数较治疗前以及血清神经元特异性烯醇化酶(Neuron specific enolase,NSE)水平均较治疗前明显降低(P0.05),且观察组以上指标均明显低于对照组(P0.05)。两组的嗜睡、皮疹、头痛、感觉异常、恶心呕吐的发生率比较差异无明显统计学意义(P0.05)。结论:注射用丹参多酚酸盐联合丙戊酸钠治疗脑卒中后癫痫的疗效明显优于单用丙戊酸钠治疗,其可更有效控制癫痫症状,且安全性较高。

Efficacy of Salvia Miltiorrhiza Polyphenolate Injection Combined with Sodium Valproate in the Treatment of Post-stroke Epilepsy

ABSTRACT Objective: To study the clinical efficacy and safety of salvia miltiorrhiza polyphenolate combined with sodium valproate for post-stroke epilepsy. Methods: Selected 80 patients with post-stroke epilepsy who were treated in Jiangbei Campus, Zhongda Hospital Affiliated to Southeast University from January 2016 to April 2019, divided into the two groups randomly. In the control group, 40 patients with post-stroke epilepsy were treated with sodium valproate alone, and 40 patients with post-stroke epilepsy in the observation group were treated with salvia miltiorrhiza polyphenolate and sodium valproate. Comparison of EEG findings and outcomes of epileptic symptoms after treatment in both groups. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group (97.50 % vs. 80 %, P<0.05). The number of involved leads, epileptiform discharge, duration of seizures, number of seizures, and in serum neuron specific enolase(NSE) levelsin the two groups were significantly lower than those before treatment(P<0.05). And the above indicators in the observation group were significantly lower than the control group (P<0.05). There was no significant difference in the incidence of sleepiness, rash, headache, abnormal sensation and nausea and vomiting between the two groups(P>0.05). Conclusion: The treatment of Danshen polyphenolate combined with sodium valproate for injection is better than the treatment with sodium valproate alone, which can control epileptic symptoms more effectively and has higher safety.