脑卒中患者D—二聚体的检测及危险因素的研究

为了了解Ｄ－二聚体和脑卒中的关系，深入探讨脑卒中发生的危险因素，对脑卒中病人及其对照进行了Ｄ－二聚体和血脂的定量测定以及危险因素分析。结果显示，病例组Ｄ－二聚体水平明显高于对照组（ｔ＝５．５６６，Ｐ＜０．０５），将病例组分为脑梗塞和脑出血后，脑梗塞组Ｄ－二聚体含量仍高于对照，而脑出血组与对照比较差别则不明显（Ｐ＞０．０５）。提示Ｄ－二聚体可作为脑血栓形成临床诊断和疗效观察的有效指标，Ｄ－二聚体水平的高低与脑卒中的类型有关。经多因素条件ｌｏｇｉｓｔｉｃ回归分析显示，脑卒中家族史、收缩压、Ｄ－二聚体为脑卒中发生的危险因素，文化程度，ＨＤＬ为保护性因素

Study on Plasma level of D dimer and Risk Factors in Stroke

In order to find out the relationship beteen D dimer and stroke, and the risk factors in the disease, D dimer and lipids in blood were measured in stroke patients and health controls. The results showed that the plasma level of D dimer in cases was higher than that in controls(t=5 566,P<0 05),After the stroke was divided into two kinds. of subtype, the D dimer level in cerebral infarction was still significant higher than that in controls, while not significant different from that in controls(P>0 05)in cerebral haemorrhage The results suggested that D dimer could be made a marker to diagnosis the forming of stroke, to evaluate the treatment. The level of D dimer was related to the type of stroke. By means of multivariate conditional logistic regression analysis, we found that the history of family stroke, systolic pressure and D dimer were the risk factors in stroke, while the level of education and HDL were the preventive factors.