肿瘤标志物在脐尿管癌诊断中的价值

目的 分析脐尿管癌患者CEA、CA199、CA724的表达情况，探索其与疾病诊断、分期、进展和治疗反应的相关性。方法 选取12例进行了相关肿瘤标志物检测的脐尿管癌患者作为研究对象，分为远处转移组4例和非转移组8例。选取40例膀胱尿路上皮癌患者和40例健康人群作为对照组。运用SPSS 23.0和MedCalc 19进行数据分析。结果 12例脐尿管癌患者均为腺癌。脐尿管癌组患者CEA表达水平明显高于尿路上皮癌组和健康对照组（P=0.01）。CA724在远处转移组中的阳性检出率明显高于非转移组（75% vs. 0, P=0.018）。单独检测时，CEA诊断脐尿管癌的AUC最大，为0.750，95%CI: 0.584~0.916。CEA、CA724联合检测与三种肿瘤标志物联合检测的AUC均大于单项检测的AUC，但差异无统计学意义（0.817 vs. 0.805, P=0.8509）。结论 脐尿管癌患者CEA表达水平明显增高，CA724可作为脐尿管癌远处转移的预测指标，且与CEA联合检测可为脐尿管癌的临床诊断提供有效参考。

Application of Tumor Markers in Patients with Urachal Carcinoma

Objective To analyze the expression of CEA, CA199 and CA724 in patients with urachal carcinoma, and to explore their correlation with disease diagnosis, staging, progression and treatment response. Methods Twelve urachal carcinoma patients with related tumor markers were selected as the research object and further divided into distant metastasis group (n=4) and non-metastasis group (n=8). We selected 40 patients with urothelial carcinoma of the bladder and 40 healthy people as the control groups. SPSS 23.0 and MedCalc 19 were used for data analysis. Results Twelve patients with urachal carcinoma were all adenocarcinomas. The expression of CEA in the urachal carcinoma group was significantly higher than that in urothelial carcinoma group and healthy control group (P=0.01). The positive rate of CA724 in the distant metastasis group was significantly higher than that in the non-metastasis group (75% vs. 0, P=0.018). In single test, CEA diagnosed urachal carcinoma with the highest AUC of 0.750 and 95%CI of 0.584 to 0.916. The AUC detected by the combination of both CEA and CA724 or three tumor markers were all larger than the AUC detected by single test, but without statistical significance (0.817 vs. 0.805, P=0.8509). Conclusion The expression of CEA in patients with urachal carcinoma is significantly increased. CA724 can be used as a predictor of distant metastasis of urachal carcinoma, and the combination detection of CA724 and CEA can provide an effective reference for the clinical diagnosis of urachal cancer.