| 血红素/G-四链体DNA酶的活性增强研究及其在生物传感器中的应用进展 |
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| 引用本文： | 莫艳红,李晖,王彬,徐晓慧,刘思思,曾冬冬.血红素/G-四链体DNA酶的活性增强研究及其在生物传感器中的应用进展[J].应用化学,2020,37(11):1249-1261. |
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| 作者姓名： | 莫艳红 李晖 王彬 徐晓慧 刘思思 曾冬冬 |
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| 作者单位： | 上海理工大学医疗器械与食品学院 上海 200093;上海健康医学院 上海 201318 |
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| 基金项目： | 上海市自然科学基金(19ZR1474300)和上海市分子影像学重点实验室建设(18DZ2260400)项目资助 |
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| 摘 要： | 血红素/G-四链体DNA酶是一类具有类过氧化物酶活性的DNA分子,因其具有出色的活性、易修饰性和可编程性,被广泛应用于生物传感器等领域。 本文先是简要介绍了G-四链体的结构,再主要综述了增强血红素/G-四链体DNA酶活性的策略及基于血红素/G-四链体DNA酶的生物传感器在生物标志物、微生物与生物毒素以及金属离子检测中的应用,并展望了血红素/G-四链体DNA酶的未来发展趋势。
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| 关 键 词： | 血红素/G-四链体 DNA酶 过氧化物酶 生物传感器 |
| 收稿时间： | 2020-05-21 |
| 修稿时间： | 2020-06-19 |
Research on the Enhanced Activity of Hemin/G-Quadruplex DNAzyme and Its Application in Biosensors |
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| MO Yanhong,LI Hui,WANG Bin,XU Xiaohui,LIU Sisi,ZENG Dongdong.Research on the Enhanced Activity of Hemin/G-Quadruplex DNAzyme and Its Application in Biosensors[J].Chinese Journal of Applied Chemistry,2020,37(11):1249-1261. |
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| Authors: | MO Yanhong LI Hui WANG Bin XU Xiaohui LIU Sisi ZENG Dongdong |
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| Affiliation: | School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai University of Medicine & Health Sciences,Shanghai 201318,China |
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| Abstract: | Hemin/G-quadruplex DNAzyme is a type of DNA molecule with peroxidase-like activity. Because of its excellent activity, easy modification and programmability, it has been widely used in biosensors and other fields. This article first briefly introduces the structure of G-quadruplex, and then reviews the strategies for enhancing hemin/G-quadruplex DNAzyme activity and application of biosensors based on hemin/G-quadruplex DNAzyme in the detection of biomarkers, microorganisms, biotoxins and metal ions. We also prospect the development trend of hemin/G-quadruplex DNAzyme. |
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| Keywords: | hemin/G-quadruplex dnazyme peroxidase biosensor |
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