| DPC4/SMAD4在子宫内膜癌中的表达及意义 |
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| 引用本文： | 葛秀君,刘志辉,李英勇.DPC4/SMAD4在子宫内膜癌中的表达及意义[J].广东药学院学报,2005,21(1):89-91. |
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| 作者姓名： | 葛秀君 刘志辉 李英勇 |
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| 作者单位： | 广东药学院,妇产科教研室,广东,广州,510240;广州中医药大学第一附属医院,检验科,广东,广州,510405;广东医学院附属医院,妇产科,广东,湛江,524001 |
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| 摘 要： | 目的探讨Smad4蛋白在子宫内膜癌中的表达情况及其意义。方法应用免疫组织化学SP方法检测 56例子宫内膜癌Smad4的表达情况,并与 30例正常子宫内膜和 42例各型增生性子宫内膜对比。结果Smad4在子宫内膜癌中的表达明显低于正常子宫内膜和单纯性增生性子宫内膜(P<0. 01,P<0. 05),且与组织学分级及临床分期明显相关 (P<0. 01,P<0. 05),而与肌层浸润深度无关。结论Smad4蛋白的表达可能在子宫内膜癌的发生发展及判断预后方面具有重要作用,可作为重要的生物学标记物。
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| 关 键 词： | Smad4蛋白 子宫内膜癌 免疫组织化学 |
| 文章编号： | 1006-8783(2005)01-0089-03 |
| 修稿时间： | 2004年9月21日 |
Expression of Smad4 protein in endometrial carcinoma and its significance |
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| GE Xiu-jun,LIU Zhi-hui,LI Ying-yong.Expression of Smad4 protein in endometrial carcinoma and its significance[J].Academic Journal of Guangdong College of Pharmacy,2005,21(1):89-91. |
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| Authors: | GE Xiu-jun LIU Zhi-hui LI Ying-yong |
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| Affiliation: | GE Xiu-jun 1,LIU Zhi-hui 2,LI Ying-yong 3 |
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| Abstract: | Objective To investigate the expression of in endometrial carcinoma and its clinical significance. Methods Smad4 protein was detected in 56 endometrial carcinoma samples and 72 normal or/and benign hypertrophic endometrium samples by immunohistochemical SP method. Results Compared with normal controls and single hyperplasia, Smad4 protein was decreased in endometrial carcinoma tissue (P<0.01, P<0.05). The expression of Smad4 was correlated with histological grade and clinical stage (P<0.01, P<0.05),while no significant difference was detected in tumors of different myometrial carcinoma samples. Conclusion Smad4 protein may play an important role in the development and prognosis of endometrial carcinoma. It may be used as an important biological marker in endometrial carcinoma. |
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| Keywords: | Smad4 protein endometrial carcinoma immunohistochemistry |
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