| 芹黄素纳米脂质载体制剂的制备及理化性质考察 |
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| 作者姓名： | Zhai YJ Guo CY Hou JN Zhang WD Zhai GX |
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| 作者单位： | 山东大学药学院; |
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| 基金项目： | 山东大学本科生创新基金立项课题(2010459) |
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| 摘 要： | 目的:制备芹黄素纳米脂质载体制剂并进行质量评价。方法:采用高温乳化-低温固化法制备芹黄素纳米脂质载体制剂,并对其形态、粒径、表面电位、包封率、载药量、体外释药等特性进行考察。结果:得到的芹黄素纳米粒为类球形,粒径分布均匀,平均粒径为212.1 nm,Zeta电位为-14.65 mV,平均包封率为82.4%,平均载药量为0.97%,体外2 h累积释药30%,随后释药过程趋于缓慢。结论:所制备的芹黄素纳米脂质载体制剂性质稳定,有良好的应用前景。
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| 关 键 词： | 芹黄素 纳米脂质载体 粒径分布 包封率 |
Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers |
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| Zhai YJ,Guo CY,Hou JN,Zhang WD,Zhai GX.Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers[J].Jorunal of Chinese Medicinal Materials,2011,34(6):962-965. |
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| Authors: | Zhai Ying-jie Guo Chen-yu Hou Jin-ning Zhang Wei-dong Zhai Guang-xi |
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| Affiliation: | ZHAI Ying-jie,GUO Chen-yu,HOU Jin-ning,ZHANG Wei-dong,ZHAI Guang-xi(College of Pharmacy,Shandong University,Jinan 250012,China) |
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| Abstract: | Objective:To prepare Apigemin-loaded nanostructured lipid carriers(Api-NLCs)and evaluate their characteristics.Methods:Api-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature.The physicochemical properties such as morphology,size distribution,zeta potential,entrapment efficiency,drug loading and drug release in vitro were evaluated.Results:The obtained nanoparticles were spherical under transmission electron microscope.The mean diameter was 212.1 nm,the zeta potential ... |
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| Keywords: | Apigemin Nanostructured lipid carriers Particle size distribution Entrapment efficiency |
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