| 二苄基亚磷酸酯的合成及纯化工艺改进 |
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| 引用本文： | 王颖煜.二苄基亚磷酸酯的合成及纯化工艺改进[J].化学试剂,2003,25(2):103-103,86. |
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| 作者姓名： | 王颖煜 |
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| 作者单位： | 中国医学科学院药物研究所,北京,100050 |
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| 摘 要： | 以苯甲醇和三氯化磷为原料，在吡啶存在下合成了二苄基亚磷酸酯。采用减压柱层析进行纯化，以V石油醚＝V乙醚=4∶1为展开剂得到含量大于80％的二苄基亚磷酸酯，其纯度与市售的二节基亚磷酸酯一致。
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| 关 键 词： | 二苄基亚磷酸酯 合成 纯化工艺 工艺改进 苯甲醇 三氯化磷 |
| 文章编号： | 0258-3283(2003)02-0103-01 |
Synthesis of dibenzyl phosphite and improvement of the orocess |
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| Wang Yingyu.Synthesis of dibenzyl phosphite and improvement of the orocess[J].Chemical Reagents,2003,25(2):103-103,86. |
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| Authors: | Wang Yingyu |
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| Abstract: | Dibenzyl phosphite was synthesized by benzyl alcohol and trichlorophosphorous in the presence of pyri-dine. The product is unstable,so it had to be purified first by distillation under reduced pressure lower than 0. 01 mmHg,it is time-consuming and difficult to carry out in the lab. In this paper, the product is purified by column chromatography under reduced pressure( petroleum ether: diethyl ether=4:1,V/V). After that, the purity of the product is better than 80 %, the same as the commercial product. |
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| Keywords: | dibenzyl phosphite synthesis improvement of process |
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