格列吡嗪联合阿卡波糖治疗2型糖尿病的临床观察

目的：比较格列吡嗪联合阿卡波糖与单用阿卡波糖（商品名拜唐苹）治疗2型糖尿病患者的临床疗效。方法：将65例单纯饮食加运动疗法治疗不满意的2型糖尿病患者随机分为两组,治疗组应用格列吡嗪联合阿卡波糖33例,对照组应用阿卡波糖32例,1个疗程为12周。定期测定并比较两组治疗前后空腹血糖（FPG）、餐后2h血糖（2hPBG）,糖化血红蛋白（HbA1c）,空腹及餐后2h胰岛素（FINS,2hPINS）和血脂。结果：治疗组FPG平均下降幅度大于对照组,两组P值均〈0.01;两种药物对2hPBG均有明显的降低作用（P〈0.01）,且降低程度相似;两组HbA1c均能显著降低,治疗组从（8.81±1.12）%降至（7.01±0.96）%（P〈0.01）,对照组从（8.75±0.71）%降至（6.95±0.92）%（P〈0.01）,两组比较HbA1c降低的幅度差异无统计学意义（P〉0.05）;餐后2h血清胰岛素与治疗前比较,治疗组升高,差异有统计学意义（P〈0.01）,而对照组明显降低（P〈0.01）。结论：两组均有明显降低空腹和餐后血糖以及HbA1c的作用,对以餐后血糖高为主的糖尿病患者更适合选用。格列吡嗪联合阿卡波糖降空腹血糖的作用优于单用阿卡波糖,而且能很好地控制继发失效2型糖尿病患者的血糖。

Clinical observation of gelie paradiazine combined with acarbose in the treatment of type 2 diabetes mellitus

Objective：To compare the clinical therapeutic efficacy of gelie paradiazine united with acarbose and only use acarbose in the treatment of type 2 diabetes mellius.Methods：Sixty five patients with type 2 diabetes mellitu were randomly divided into two groups and treated for 12 weeks.The treatment group（n=33） were given gelie paradiazine united with acarboseor.Control group（n=32） were given acarbose.The values of FPG,2hPBG,HbAlc,FINS,2hPINS and blood-fat were compared before and after treatment.Results：The FPG coming down averagely of the treatment group was greater than that of the control group（P〈0.01）.Both drugs could reduce the value of 2hPBG significantly（P〈0.01）,which had similar effects as well.The levels of HbA1c were significantly decreased in two groups,the concentrations of HbA1c reduced from（8.81±1.12）% to（7.01±0.96）% in the treatment group（P〈0.01）,and from（8.75±0.71）% to（6.95±0.92）% in the control group（P〈0.01）,but without statistically significant difference between the two groups（P〉0.05）.The values of P2hINS were significantly increased（P〈0.01） in treatment group,but were significantly decreased（P〈0.01） in control group.Conclusion：The values of FPG,P2hBG and HbA1c were significantly decreased in both groups.Gelie paradiazine united with acarbose are more suitable for treatment of patients whose value of P2hBG are increased apparently after diet.The effect of gelie paradiazine united with acarbose is better than that of acarboae in reducing FPG,thus is more suitable to control type 2 di abetics.