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| 多元分析模板图在监测肝移植受者FK506治疗窗浓度中的应用 | |
| 引用本文： | 马嵘,胡翠华,刘桂芹,乔江春,谢洁红,张传宝,郭健.多元分析模板图在监测肝移植受者FK506治疗窗浓度中的应用[J].微循环学杂志,2010,20(3):41-43. |
| 作者姓名： | 马嵘 胡翠华 刘桂芹 乔江春 谢洁红 张传宝 郭健 |
| 作者单位： | 1. 卫生部临床检验中心,北京,100730 2. 卫生部北京医院病案室 3. 卫生部北京医院外科 |
| 摘 要： | 目的:应用多元分析模板图为临床肝移植受者监测他可莫司(代号FK506)理想治疗窗浓度提供方法。方法:用Excel软件建立标准品、质控品和患者样本的多元分析模板图,对微粒子酶免疫分析法(MEIA)测定的肝移植受者全血FK506血药浓度数据进行处理。结果:为11例肝移植受者检测FK506血药浓度178例次,术后3个月内在理想治疗窗浓度范围内者占44.6 %,异常标准曲线5条,质控值失控3次。结论:多元分析模板图操作简单,使用方便,是监测FK506治疗窗浓度的实用工具。 |
| 关 键 词： | 多元分析模板图 FK506 肝移植受者 治疗窗浓度 微粒子酶免疫分析法 |
The Multianalysis Templet Chart for FK506 Therapeutic Window Concentration in Liver Transplant Recipients |
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| Abstract: | Objective:To give some information for FK506 ideal therapeutic window concentration in liver transplant recipients.Method:The multianalysis templet charts of calibrator,control and patents sample were developed through Excel soft,in order to handle the data of FK506 whole blood concentration determined via micro-particle enzyme immunoassay (MEIA).Results:The FK506 blood concentration were measured for 178 cases in 11 liver transplant recipients,and the ideal therapeutic window concentrations were accounted for 44.6% within three months after transplantation,along with 5 abnormal calibrator curve and 3 out of control.Conclusion:The multianalysis templet charts were simple,convenient and applied tool to carry out blood drug concentration monitoring. |
| Keywords: | FK506 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
