| 基质金属蛋白酶在多发性硬化发病中的作用机制及治疗现状 |
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| 引用本文： | 董梅.基质金属蛋白酶在多发性硬化发病中的作用机制及治疗现状[J].国际免疫学杂志,2007,30(1):35-38. |
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| 作者姓名： | 董梅 |
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| 作者单位： | 050000,石家庄,河北医科大学第二医院神经内科 |
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| 摘 要： | 多发性硬化（MS）是中枢神经系统炎性脱髓鞘疾病，基质金属蛋白酶是一组蛋白水解酶，有重要的病理和生理作用，近年的研究表明它在（MS）的发生和疾病进展中都具有重要作用，参与主要的发病过程，具有多种发病机制，抑制其活性具有有效的治疗意义。
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| 关 键 词： | 多发性硬化 基质金属蛋白酶 发病机制 |
| 修稿时间： | 2006-01-26 |
Mechanism of matrix metalloproteinases in the pathogenic course of multiple sclerosis and the related therapeutic applications |
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| DONG Mei.Mechanism of matrix metalloproteinases in the pathogenic course of multiple sclerosis and the related therapeutic applications[J].International Journal of Immunology,2007,30(1):35-38. |
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| Authors: | DONG Mei |
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| Affiliation: | The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China |
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| Abstract: | Multiple sclerosis(MS) is characterized by demyelination and inflammation of the central nervous system(CNS).Matrix metalloproteinases(MMPs) are proteolytic enzymes and have important functions in both pathological and physiological conditions.Recent studies showed that MMPs are crucial pathogenetic effectors and play a central role in the happen of MS and the lesion formation.Inhibiting MMPs' activity may lead to an effective therapy against MS. |
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| Keywords: | Multiple sclerosis Matrix metalloproteinase Pathogenesis |
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