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Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease |
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| Authors: | Jack A Wells Holly E Holmes James M O'Callaghan Niall Colgan Ozama Ismail Elizabeth MC Fisher Bernard Siow Tracey K Murray Adam J Schwarz Michael J O'Neill Emily C Collins Mark F Lythgoe |
| Affiliation: | 1UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK;2Department of Neurodegenerative Disease, Institute of Neurology, UCL, London, UK;3Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK;4Tailored Therapeutics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA |
| Abstract: | Vascular abnormalities are a key feature of Alzheimer''s disease (AD). Imaging of cerebral vascular reactivity (CVR) is a powerful tool to investigate vascular health in clinical populations although the cause of reduced CVR in AD patients is not fully understood. We investigated the specific role of tau pathology in CVR derangement in AD using the rTg4510 mouse model. We observed an increase in CVR in cortical regions with tau pathology. These data suggest that tau pathology alone does not produce the clinically observed decreases in CVR and implicates amyloid pathology as the dominant etiology of impaired CVR in AD patients. |
| Keywords: | Alzheimer''s arterial spin labelling cerebral vascular reactivity MRI tau |
