| 正交优选苗药验方隔梨胃炎消提取工艺 |
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| 引用本文： | 罗春丽,李金玲,刘红昌,王华磊,赵致.正交优选苗药验方隔梨胃炎消提取工艺[J].中国实验方剂学杂志,2010,16(18):129-131. |
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| 作者姓名： | 罗春丽 李金玲 刘红昌 王华磊 赵致 |
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| 作者单位： | 贵州大学农学院中药材研究所,贵州省药用植物繁育与种植重点实验室,贵阳,550025 |
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| 基金项目： | 贵州省中药材现代产业技术体系建设专项(GZCYTX-02)资助;贵州省中药材资源保护与可持续利用研究创新团队([2010]4006);贵州省科技厅重点实验室计划项目([2010]4015)。 |
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| 摘 要： | 目的:优选苗药验方治疗慢性胃炎的提取工艺。方法:选取水和乙醇作为提取溶媒,以溶剂浓度、溶剂用量、提取时间、提取次数及药材粉碎粒度作为考察因素,每个因素设立3个水平;并以提取物的镇痛、抗炎作用,浸出物为指标,利用L9(34)正交设计优选提取工艺。结果:水提最佳提取工艺为粉碎粒度为粗颗粒,加10倍量水,提取1 h,提取3次;醇提最佳提取工艺为粉碎粒度为最粗粉,加10倍量乙醇,提取2 h,乙醇浓度为70%,提取2次。考虑到节约成本以及考察指标浸出物、镇痛率、抗炎率的结果显示水提组均优于醇提组;最终确定提取工艺为水提,药材粉碎粒度为粗颗粒,加10倍量水,提取1 h,提取3次。结论:优选的提取工艺稳定,提取物药效显著。
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| 关 键 词： | 隔梨胃炎消 提取工艺 镇痛作用 抗炎作用 |
| 收稿时间： | 2010/5/24 0:00:00 |
Optimization of Extraction Techniques for Geli Weiyanxiao by Orthogonal Experiment |
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| LUO Chun-li,LI Jin-ling,LIU Hong-chang,WANG Hua-lei and ZHAO Zhi.Optimization of Extraction Techniques for Geli Weiyanxiao by Orthogonal Experiment[J].China Journal of Experimental Traditional Medical Formulae,2010,16(18):129-131. |
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| Authors: | LUO Chun-li LI Jin-ling LIU Hong-chang WANG Hua-lei and ZHAO Zhi |
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| Affiliation: | College of Agronomy,Guizhou University, The Key laboratory of Propagation and Cultiration for Medicinal Plants of Guizhou Province, Guiyang 550025, China;College of Agronomy,Guizhou University, The Key laboratory of Propagation and Cultiration for Medicinal Plants of Guizhou Province, Guiyang 550025, China;College of Agronomy,Guizhou University, The Key laboratory of Propagation and Cultiration for Medicinal Plants of Guizhou Province, Guiyang 550025, China;College of Agronomy,Guizhou University, The Key laboratory of Propagation and Cultiration for Medicinal Plants of Guizhou Province, Guiyang 550025, China;College of Agronomy,Guizhou University, The Key laboratory of Propagation and Cultiration for Medicinal Plants of Guizhou Province, Guiyang 550025, China |
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| Abstract: | Objective: To optimize the extraction techniques of Geli Weiyanxiao. Method: The selection of optimum proess was investigated by L9(34) orthogonal design with the Geli Weiyanxiao as the observation index. Result: Water extraction process: to smash the best size for coarse particles, plus 10 times the volume of water, from 1 hour, 3 times. Ethanol extraction process: to smash the best size for 10 mesh number, adding10-fold 70% ethanol, eatracting for 2 times, 2 hours for each extraction; In consideration of cost-saving and the results of various indexes, the optimal process condition was selected as follows: the best size for coarse particles, plus 10 times the volume of water, from 1 hour, 3 times. Conclusion: The optimal extraction technique for Geli Weiyanxiao is stable and reliable. |
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| Keywords: | Geli Weiyanxiao extraction technique analgesic effect anti-inflammatory action |
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