| 凝血系统的异常与肺间质纤维化 |
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| 引用本文： | 班承钧,代华平.凝血系统的异常与肺间质纤维化[J].国际呼吸杂志,2007,27(15):1165-1169. |
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| 作者姓名： | 班承钧 代华平 |
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| 作者单位： | 100020,首都医科大学附属北京朝阳医院-北京呼吸疾病研究所 |
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| 摘 要： | 间质性肺疾病（ILD）是以肺间质纤维化为最终表现的一组异质性疾病谱，临床观察发现间质性肺疾病患者肺内存在凝血功能亢进，纤溶及抗凝功能的抑制，患者支气管肺泡灌洗液内凝血酶-抗凝血酶复合物（TAT）、组织因子（TF）水平升高，尿激酶型纤溶酶原激活物（uPA）、活化蛋白C（APC）水平降低，纤溶酶原激活物抑制物（PAI-1）、蛋白C抑制物（PCI）水平升高，本文通过对国外相关文献的复习，阐述了凝血系统的这种异常变化与间质性肺疾病患者肺纤维化的关系。
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| 关 键 词： | 间质性肺疾病 凝血 纤溶 间质纤维化 |
| 修稿时间： | 2006-10-16 |
Abnormal state of coagulation and pulmonary fibrosis |
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| BAN Cheng-jun,DAI Hua-ping.Abnormal state of coagulation and pulmonary fibrosis[J].International Journal of Respiration,2007,27(15):1165-1169. |
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| Authors: | BAN Cheng-jun DAI Hua-ping |
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| Affiliation: | Beijing Institution of Respirotary Disease ,Beijing Chaoyang Hospital affiliated to Capital Medical University ,Beijing 100020 , China |
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| Abstract: | The objects of this article are to review the evidence that abnormal state of coagulation in patients with interstitial lung disease (ILD); to describe the profibrotic effects of coagulation protease and involved mechanism; and to provide evidence for the abnormal state of coagulation may contribute to pulmonary fibrosis. |
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| Keywords: | Coagulation protease Interstitial lung disease Pulmonary fibrosis |
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