Toll样受体4的研究及现状

Toll样受体4（Toll-like receptor4，TLR4）是天然免疫系统识别病原微生物的主要受体，在天然免疫反应中具有重要的作用。TLR4细菌脂多糖（1ipopolysaeeharide，LPS）是介导信号跨膜转导的主要受体，对于革兰氏阴性菌的感染性炎症至关重要。近年来，有关TLR4介导的信号转导及其TLR4与疾病的关系受到人们的关注。本文就TLR4的信号转导、TLR4与LPS的关系进行了综述，并介绍了TLR4与相关疾病之间的关系，对TLR4的研究意义进行了肯定。

Advancement of toll-like receptor 4

Toll-like receptors are main receptors for the innate immune system to recognize pathogenic microorganisms and thus educe very important effect in the innate immune reactions.Toll-like receptor 4(TLR4) is one of the major receptors which mediates the signal's transmembrane transduction,and is of great important to the infective inflammation caused by Gram-negative bacteria.Recently,more and more researchers paid close attention to TLR4 and its signal transduction mechanisms.This review describes the signaling transduction of TLR4,the relationships between TLR4 and lipopolysaccharide(LPS),TLR4 and diseases,confirms the significance of TLR4 research.