宫颈癌组织中β-Catenin和NF—κB的表达及意义

目的：检测β-连环蛋白（β—Catenin）和核因子-κB（NF—κB）在宫颈癌组织中的表达情况及临床意义。方法：采用免疫组化染色技术分别检测48例宫颈癌及20例正常宫颈组织中β-Catenin及NF—κB的表达情况。结果：β-Catenin和NF—KB在宫颈癌组织中的阳性表达率分别为68．75％（33／48）和60．42％（29／48），而两者在正常宫颈组织中的阳性表达率分别为5．00％（1／20）和20．00％（4／20），差异有统计学意义（P〈0．05）。β-Catenin阳性表达与宫颈癌临床分期（P=0．044）和病理学分级（P=0．008）相关，而NF—κB阳性表达与宫颈癌临床分期（P=0．012）、淋巴结转移（P=0．007）和病理学分级（P=0．000）相关。结论：宫颈癌组织中β-Catenin和NF—κB表达升高且与恶性临床参数相关，β-Cate—nin和NF—κB可能作为宫颈癌的潜在治疗靶点和预后预测因子。

Evaluation of β-Catenin and NF-κB expression and its significance in cervical cancer

Objective= To investigate the expression of β-Catenin and NF-κB in cervical cancer tis- sues and its clinical significance. Methods= We detected β-Catenin and NF-κB expression in 48 samples of surgically resected cervical cancer and 20 samples of normal cervix tissues using immunohistochemistry. Results. The positive rate of β-Catenin and NF-κB in cervical cancer tissues （68.75% and 60.42%） were significantly up-regulated compared to those of the normal cervix tissues （5.00% and 20.00%） （x2 = 22. 950, P=0. 000;x2= 9. 232, P= 0. 002）. The positive expression of β-Catenin was significantly correlated with clinical stages （P=0.044） and pathological grades （P=0. 008）, the positive expression of NF-κB was significantly correlated with clinical stages （P=0. 012）, lymph node metastasis （P=0. 007） and patholog- ical grades （P=0. 000）. Conclusion. The expression of β-Catenin and NF-κB increase obviously and are as- sociated with abnormal clinical parameters in cervical cancer. β-Catenin and NF-κB may act as therapeutictargets and prognostic actors in cervical cancer.