| 健脾补肾法对拉米夫定治疗慢性乙型肝炎的增效作用及其与Th1/Th2的相关性 |
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| 引用本文： | 刘肄辉,张永华,韩颖.健脾补肾法对拉米夫定治疗慢性乙型肝炎的增效作用及其与Th1/Th2的相关性[J].中国中西医结合消化杂志,2008,16(6). |
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| 作者姓名： | 刘肄辉 张永华 韩颖 |
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| 作者单位： | 浙江省中西医结合医院,肝病科,浙江,杭州,310000 |
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| 基金项目： | 浙江省科技厅一般项目
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| 摘 要： | 目的]观察健脾补肾法对拉米夫定治疗慢性乙型肝炎(CHB)的增效作用及其与辅助性T细胞Th1/Th2的相关性.方法]120例CHB E-抗原阳性患者,随机分为2组,观察组采用健脾补肾中药联合拉米夫定治疗,对照组仅用拉米夫定治疗,定期观察肝功能、乙肝三系、乙肝病毒核酸(HBV-DNA)、酪氨酸-蛋氨酸-天门冬氨酸-天门冬氨酸(YMDD)变异等指标,疗程均为1 a.疗程结束后2组各随机抽取30例,采集外周血检测干扰素γ(IFNγ)和白细胞介素4(IL-4).结果]观察组与对照组相比,在缩短肝功能、病毒载量恢复时间,提高E-抗原(HBeAg)转换率、延长YMDD变异时间等方面均有统计学意义(均P<0.05),观察组治疗后IFN-γ明显高于对照组,IL-4明显低于对照组,差异均有统计学意义(均P<0.05).结论]健脾补肾中药能够提高拉米夫定治疗CHB的疗效,其与Th1/Th2相关.
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| 关 键 词： | 乙型肝炎 慢性 健脾补肾 拉米夫定 |
Synergy effect of Jianpi Bushen method on Chronic hepatitis B treated by Lamivudine and relationship with Th1/Th2 |
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| LIU Yi-hui,ZHANG Yoong-hua,HAN Ying.Synergy effect of Jianpi Bushen method on Chronic hepatitis B treated by Lamivudine and relationship with Th1/Th2[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2008,16(6). |
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| Authors: | LIU Yi-hui ZHANG Yoong-hua HAN Ying |
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| Affiliation: | LIU Yi-hui,ZHANG Yong-hua,HAN Ying(Zhejiang Hospital of Integrated Traditional , Western Medicine,Hangzhou 310000,China) |
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| Abstract: | Objective]To observe the synergy effect of Jianpi Bushen metod on Chronic hepatitis B treated by Lamivudine and the relationship with Th1/Th2.Methods]One huadred and twenty patients,with HBeAg positive were divided into two groups at random:observation groupand control group,each group having sixty patients.Patients in the control group were only given to Lamivudine.Patients in the observation group were given to Lamivudine and traditional Chinese drug.Observation item:liver function,HBV-DNA,HBeAg,YMDD.Th... |
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| Keywords: | Th1/Th2 |
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