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肿瘤干细胞研究进展
引用本文:潘秋辉,;宋尔卫.肿瘤干细胞研究进展[J].生命科学,2009(5):715-719.
作者姓名:潘秋辉  ;宋尔卫
作者单位:[1]中山大学附属第二医院医学研究中心,广州510120; [2]中山大学附属第二医院乳腺外科,广州510120
基金项目:基金项目:国家自然科学基金重点项目(30830110);国家自然科学基金面上项目(30600328)
摘    要:在过去的十年中,肿瘤干细胞(cancer stem cell/tumor—initiating cell,CSC/TIC)虽然受到广泛重视,但也是争论的焦点。如何正确认识CSCs假说,以及CSCs的生物学特点和CSCs的治疗应用这些问题都存在巨大的争议。该文对CSCS的起源、分离鉴定的方法,以及信号通路、微环境等对cSCS的调控关系,肿瘤的最佳治疗途径等问题进行综述。

关 键 词:干细胞  肿瘤干细胞  肿瘤治疗  分选鉴定

Research progress of cancer stem cells
Affiliation:PAN Qiu-hui, SONG Er-wei (1 Medical Research Center, second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China; 2 Department of Breast Surgery, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China)
Abstract:The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past decade but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following text, we discuss the origin, the identification, regulatory pathway, microenviroment and the new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.
Keywords:stem cell  cancer stern cell  cancer therapy  identification of sorting
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