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| 分层分析在药品不良反应信号检测中的应用 | |
| 引用本文： | 赵璐,叶小飞,王超,钱维,杜文民,贺佳.分层分析在药品不良反应信号检测中的应用[J].中国药物警戒,2011,8(3):158-160. |
| 作者姓名： | 赵璐 叶小飞 王超 钱维 杜文民 贺佳 |
| 作者单位： | 1. 第二军医大学卫生统计学教研室,上海200433;第二军医大学研究生管理大队,上海200433 2. 第二军医大学卫生统计学教研室,上海,200433 3. 上海市药品不良反应监测中心,上海,200040 |
| 基金项目： | 国家自然科学基金资助项目，上海市优秀学科带头人计划(A类) |
| 摘 要： | 药品上市后不良反应监测无法实现用药人群的随机化,因此无法控制数据中的混杂偏倚。如何在分析数据时控制可疑混杂因素的影响,准确有效地检测出信号,一直是国内外关注的焦点。通过采用分层分析的思想控制混杂因素,将上海市2009年药品不良反应监测中心的数据用三种方法进行分析,比较分层前后混杂因素对信号检测的影响,以期为药品上市后不良反应的准确监测提供帮助。 |
| 关 键 词： | 混杂 分层分析 信号检测 |
Application of Stratification Analysis in Adverse Drug Reaction Signal Detection |
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| ZHAO Lu,YE Xiao-fei,WANG Chao,QIAN Wei,DU Wen-min,HE Jia.Application of Stratification Analysis in Adverse Drug Reaction Signal Detection[J].Chinese JOurnal of Pharmacovigilance,2011,8(3):158-160. | |
| Authors: | ZHAO Lu YE Xiao-fei WANG Chao QIAN Wei DU Wen-min HE Jia |
| Affiliation: | ZHAO Lu1,2 YE Xiao-fei1 WANG Chao1 QIAN Wei1 DU Wen-min3 HE Jia1(1Department of Health Statistics,Second Military Medical University,Shanghai 200433,China,2Brigade of Graduate Student Management,3Adverse drug reaction monitoring center of Shanghai,Shanghai 200040,China) |
| Abstract: | As is well known,it is impossible to allocate the drug users in a randomized way under the post-marketing surveillance.Therefore,it is hard to control the confounding factor in signal detection of adverse drug reaction(ADR) databases.It is important to control the potential confounding effects during the analysis of ADR databases and detect signals in a more accurate way.This article briefly used the method of stratification analysis in controlling confounding factors.We analyzed the spontaneous reporting d... |
| Keywords: | confounding stratification analysis signal detection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
