| 紫菜多糖PY4对免疫细胞增殖的影响 |
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| 引用本文： | 紫菜多糖PY4对免疫细胞增殖的影响[J]. 中国药科大学学报, 2001, (1): 59-61. |
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| 作者姓名： | 张伟云 刘宇峰 陈颢 傅健 侯亚义 谭仁祥 |
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| 作者单位： | 1. 南京大学医学院
2. 南京大学生命科学学院， 南京 210093 |
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| 摘 要： | 目的：分析紫菜多糖的性质，测定其对免疫细胞增殖的影响。方法：将纯化得到的紫菜多糖PY4，用紫外和红外光谱进行鉴定。采用体外培养方法测定了PY4对小鼠骨髓细胞，脾 脏细胞，胸腺细胞的生长以及混合淋巴细胞反应的影响。结果：在骨髓细胞，脾脏淋巴细胞和胸腺淋巴细胞的增殖试验中给药组与对照组之间有非常显著的差异，而混合淋巴细胞反应中两者没有差异。结论：多糖PY4对小鼠骨髓细胞，脾 脏淋巴细胞和胸腺淋巴细胞增殖有一定的抑制作用，而对混合淋巴细胞反应没有明显的影响。
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| 关 键 词： | 条斑紫菜 紫菜多糖 PY4 免疫细胞增殖 免疫调节剂 |
| 文章编号： | 1000-5048(2001)01-0057-03 |
| 修稿时间： | 2000-07-03 |
The Effects ofPolysaccharide from Porphyra Yezoensis Ueda on Proliferation of Lymphocytes |
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| The Effects ofPolysaccharide from Porphyra Yezoensis Ueda on Proliferation of Lymphocytes[J]. Journal of China Pharmaceutical University, 2001, (1): 59-61. |
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| Authors: | ZHANG Wei Yun LIU Yu Feng CHEN Hao FU Jian HOU Ya Yi TAN Ren Xiang Medical School Nanjing University |
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| Affiliation: | ZHANG Wei Yun 1,LIU Yu Feng 1,CHEN Hao 2,FU Jian 1,HOU Ya Yi 1,TAN Ren Xiang 2 1Medical School,Nanjing University, 2Department of Biological Science and Technology,Nanjing University,Nanjing 210093,P. R. China |
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| Abstract: | AIM: To analyze the property of the polysaccharide PY4 from %Porphyra yezoensis% and to study its effects on proliferation of lymphocytes. METHODS: PY4 was identified by UV and IR spectra. The effects of PY4 on immunological function were studied by cell culture techniques. RESULTS: There were very different between the treated groups and control group on proliferation of murine bone marrow cells, spleen cells and thymus cells %in vitro%. However, no difference was on mixed lymphocyte reaction. CONCLUSION: Polysaccharide PY4 could inhibit the proliferation of murine bone marrow cells, spleen cells and thymus cells. There was no distinct effect on mixed lymphocyte reaction. |
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| Keywords: | Polysaccharide %Porphyra yezoensis % lymphocyte proliferation |
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