| UCP2:解偶联蛋白家族的新成员 |
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| 引用本文： | 关莉莉,邹原.UCP2:解偶联蛋白家族的新成员[J].大连医科大学学报,2003,25(4):296-299. |
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| 作者姓名： | 关莉莉 邹原 |
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| 作者单位： | 大连医科大学,生理学教研室,辽宁,大连,116027 |
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| 摘 要： | 解偶联蛋白 2 (uncouplingprotein 2 ,UCP2 )是解偶联蛋白家族的新成员 ,位于线粒体内膜上的阳离子载体蛋白。它可以引起质子的渗漏 ,使氧化磷酸化解偶联 ,ATP合成减少 ,能量以热的形式散失。UCP2 广泛分布于人体各组织器官。UCP2 主要参与能量代谢和脂代谢调节 ,但其广泛分布和轻微解偶联作用提示它的意义可能不仅限于此。目前UCP2 与氧化损伤的关系以及在脏器疾病中的作用已引起人们的关注。本文概述UCP2 的分布、作用及其表达调节。
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| 关 键 词： | 解偶联蛋白 能量代谢 活性氧 糖尿病 |
| 文章编号： | 1671-7295(2003)04-0296-04 |
| 修稿时间： | 2002年12月10 |
UCP2:New member of uncoupling protein family |
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| GUAN Li-li and ZOU Yuan.UCP2:New member of uncoupling protein family[J].Journal of Dalian Medical University,2003,25(4):296-299. |
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| Authors: | GUAN Li-li and ZOU Yuan |
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| Affiliation: | Department of Physiology, Dalian Medical University, Dalian 116027, China;Department of Physiology, Dalian Medical University, Dalian 116027, China |
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| Abstract: | Uncoupling proteine 2 (UCP 2 ) is localized in the inner membrane of the mitochondria in diverse tissues which may decrease mitochondrial membrane potential , deprive the driving force of ATP synthase from catalyzing ATP synthesis and dissipate energy in the form of heat. The regulator of UCP 2 mRNA include free fatty acids, leptin and etc. The previous study were mainly concentrate on the regulatory function of UCP 2 on energy metabolism and lipid metabolism. But its various function was suggested by its characteristic of wild distribution and mild uncoupling . Now evidence is accumulating that UCP 2 may play a role in regulating mitochondial production of reactive oxygen species and in some visceral diseases. |
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| Keywords: | uncoupling proteins energy metabolism reactive oxygen species diabetes mellitus |
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