| 线粒体途径在肝脏缺血再灌注损伤中的作用的研究进展 |
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| 引用本文： | 林杰,曾仲.线粒体途径在肝脏缺血再灌注损伤中的作用的研究进展[J].中华肝胆外科杂志,2020(1):69-72. |
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| 作者姓名： | 林杰 曾仲 |
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| 作者单位： | 昆明医科大学第一附属医院器官移植中心 |
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| 基金项目： | 国家自然科学基金(81660113,81760119)。 |
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| 摘 要： | 肝胆外科手术常发生肝脏缺血再灌注损伤,并且术后肝功能恢复及预后与之密切相关。虽然肝脏缺血再灌注损伤的机制复杂多样,但线粒体结构功能障碍是重要的参与者。本综述旨在总结肝脏缺血再灌注过程中线粒体变化、线粒体自噬和凋亡在缺血再灌注损伤中的作用。为减轻肝脏缺血再灌注损伤提供新靶点和新思路。
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| 关 键 词： | 再灌注损伤 肝脏 线粒体 |
Effect of mitochondrial pathway on hepatic ischemia-reperfusion iiijury |
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| Lin Jie,Zeng Zhong.Effect of mitochondrial pathway on hepatic ischemia-reperfusion iiijury[J].Chinese Journal of Hepatobiliary Surgery,2020(1):69-72. |
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| Authors: | Lin Jie Zeng Zhong |
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| Affiliation: | (Organ Transplantation Center,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China) |
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| Abstract: | Hepatic ischemia-reperfusion injury is often occurred during the hepatobiliary surgery,and is closely correlated with postoperative of liver function recovery and prognosis.Although the mechanisms of hepatic ischemia-reperfusion injury are complex,mitochondrial structural dysfunction is an important event for hepatic ischemia-reperfusion injury.This review summarized the current mechanism of hepatic ischemia-reperfusion injury,and with a focus on mitigating its damage through the mitochondrial autophagy and apoptosis pathway. |
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| Keywords: | Reperfusion injury Liver Mitochondria |
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