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| 高血压大鼠肿瘤坏死因子和一氧化氮/一氧化氮合酶系统相关性的研究 | |
| 引用本文： | 韦宜山,刘万林,李春跃,黄洁.高血压大鼠肿瘤坏死因子和一氧化氮/一氧化氮合酶系统相关性的研究[J].内蒙古医学杂志,2006,38(2):100-103. |
| 作者姓名： | 韦宜山 刘万林 李春跃 黄洁 |
| 作者单位： | 1. 内蒙古医学院第二附属医院小儿骨科,内蒙古,呼和浩特,010030 2. 内蒙古医学院生理教研室,内蒙古,呼和浩特,010059 3. 内蒙古医学院附属医院骨科,内蒙古,呼和浩特,010050 |
| 摘 要： | 目的:探讨肿瘤坏死因子(TNF)和一氧化氮(NO)/一氧化氮合酶(NOS)系统在应激性高血压发病中的作用。方法:以电击大鼠足底结合噪音复合刺激制作慢性应激性高血压大鼠(CSHR)模型,采用特异性放射免疫测定技术和化学比色法,检测CSHR和正常血压Wistar大鼠血清中TNF以及血清、心肌和主动脉血管组织NO及NOS的含量。结果:CSHR的尾动脉收缩压(CASP)明显高于Wistar大鼠(P<0.01)。CSHR的血清TNF明显高于Wistar大鼠(P<0.01),而血清、心肌和主动脉血管组织NO及NOS水平则低于Wistar大鼠(P<0.05)。结论:应激刺激作用下TNF增多和NO/NOS系统功能低下可能是造成慢性应激大鼠血压升高的重要因素。 |
| 关 键 词： | 慢性应激性高血压 肿瘤坏死因子 一氧化氮/一氧化氮合酶系统 |
| 文章编号： | 1004-0951（2006）02-0100-04 |
| 收稿时间： | 2005-09-25 |
| 修稿时间： | 2005-09-25 |
Correlation Between Tumor Necrosis Factor and Nitric Oxide / Nitric Oxide Synthase System in Rats with Hypertension |
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| WEI Yi-shan,LIU Wan-lin,YI Chun-yue,HUANG Jie.Correlation Between Tumor Necrosis Factor and Nitric Oxide / Nitric Oxide Synthase System in Rats with Hypertension[J].Inner Mongolia Medical Journal,2006,38(2):100-103. | |
| Authors: | WEI Yi-shan LIU Wan-lin YI Chun-yue HUANG Jie |
| Affiliation: | 1. Department of Pediatric Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical College, Huhhot 010030 China ; 2. Department of Physiology, Inner Mongolia Medical College, Huhhot 010059 China ; 3. Department of Orthopaedics, The Affiliated Hospital of Inner Mongolia Medical College, Huhhot 010050 China |
| Abstract: | Objective:To investigate the effect of tumor necrcsis factor(TNF) and nitric oxide(NO)/nitric oxide synthase(NOS) system in stress-induced hypertension.Methods:The model of chronic stress-induced hypertensive rats(CSHR) was induced by chronic foot-shock and noise stress in adult male wistar rats.The levels of serum TNF and NO/NOS in serum,myocardium and aortic vascular tissues were measured by chemical colorimetry method and radioimmunoassay in CSHR and normal wistar rats.Results:Caudal arterial systolic pressure(CASP) and the level of serum TNF in CSHR were significantly higher than those in wistar rats(P<0.01,P<0.01).The levels of NO/NOS in serum,myocardium and aortic vascular tissues were significantly lower in CSHR than those in wistar rats(P<0.05).Conclusion:Increasing TNF and decreasing function of NO/NOS system induced by stress stimulus are important factors in the occurance of chronic stress-induced hypertension. |
| Keywords: | Chronic stress-induced hypertension Tumor necrosis factor(TNF) Nitric oxide/nitric oxide synthase system(NO/NOS) |
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