超声技术综合评价颈动脉粥样硬化与冠心病病变程度的相关性研究

目的应用超声技术综合评价颈动脉粥样硬化与冠状动脉粥样硬化性心脏病(冠心病)病变程度的相关性。方法选取颈动脉斑块患者268例,根据其是否患有冠心病,分为冠心病组和非冠心病组,其中冠心病组患者147例,非冠心病组患者121例。超声测量颈动脉内中膜厚度(IMT)、利用血管斑块定量分析(VPQ)软件自动获取颈动脉斑块的相关参数。统计两组性别、吸烟史、糖尿病史及高血压病史等基本资料及颈动脉斑块相关超声参数,分析颈动脉粥样硬化相关参数与冠状动脉(冠脉)病变程度的相关性。结果冠心病组患者颈动脉斑块的GSM值、IMT值与非冠心病组差异有统计学意义(P<0.05);血总胆固醇、三酰甘油、低密度脂蛋白在两组间差异有统计学意义(P<0.05),且冠心病组高于非冠心病组;进一步分析显示随着冠脉病变累及支数及Gensini积分的增加,IMT与之呈正相关,而GSM呈负相关。冠心病-非冠心病组间患者的年龄、性别、吸烟史、糖尿病史、高血压病史、高密度脂蛋白、斑块厚度、斑块体积、血管腔面积、管壁面积、标准化管壁指数等斑块其它参数比较,差异均无统计学意义(P>0.05)。结论利用超声技术对颈动脉粥样硬化相关参数定量分析,在冠心病病变程度的临床预测中具有一定参考价值。

The correlation between carotid atherosclerosis and coronary heart disease evaluated by ultrasound

Objective To comprehensively evaluate the correlation between carotid atherosclerosis and the severity of coronary heart disease using ultrasound technology.Methods 268 patients with carotid artery plaque were selected,including 147 patients with coronary heart disease in the coronary heart disease group and 121 patients without coronary heart disease in the no-coronary heart disease group.Ultrasonic scanning was used to measure carotid intima-media thickness(IMT),and VPQ software was used to obtain relevant parameters of carotid plaque automatically.The basic data of two groups of gender,smoking history,diabetes history and hypertension history and carotid plaque related ultrasound parameters were analyzed,and the correlation between carotid atherosclerosis related parameters and the degree of coronary artery disease was analyzed.Results The GSM and IMT values of carotid plaque in patients with coronary heart disease were significantly different from those in noncoronary heart disease group(P<0.05).The total blood cholesterol,triglyceride,and low-density lipoprotein were statistically significant between the two groups(P<0.05),and the coronary heart disease group was higher than the non-coronary heart disease group.Further analysis shows that with the increase in the number of coronary artery lesions involved and the increase of Gensini score,IMT is positively correlated with it,while GSM is negatively correlated.Comparison between coronary heart disease group and non-coronary heart disease group,there was no statistically significant difference with respect to age,gender,smoking history,diabetes history,hypertension history,high density lipoprotein,plaque thickness,plaque volume,vascular lumen area,tube wall area and standardized tube wall(P>0.05).Conclusion Quantitative analysis of carotid atherosclerosis related parameters using ultrasound technology has certain reference value in the clinical prediction of coronary heart disease.