| LTP的钙离子通道机制:VDCC LTP和NMDA LTP |
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| 引用本文： | 田文娟,田心.LTP的钙离子通道机制:VDCC LTP和NMDA LTP[J].国际生物医学工程杂志,2008,31(2). |
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| 作者姓名： | 田文娟 田心 |
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| 作者单位： | 天津神经病学研究所,天津医科大学,300070 |
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| 基金项目： | 国家自然科学基金，教育部高校博士点专项研究基金 |
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| 摘 要： | 长时程增强(LTP)与学习记忆机制关系密切.长时程增强的产生依赖于钙离子通道的活动特性,Ca2+经不同的钙离子通道内流引发的长时程增强对应不同的记忆作用.综述了通过N-甲基-D-天门冬氨酸(NMDA)受体钙离子通道和电压依赖性钙离子通道(VDCC)活动产生LTP及其各自对应的记忆作用,还介绍了以低频刺激方式产生长时程增强的研究实例.
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| 关 键 词： | 长时程增强 记忆 N-甲基-D-天门冬氨酸受体通道 电压依赖性钙离子通道 低频刺激 |
Voltage-dependent calcium channel(VDCC)LTP and N-methyl-D-aspartate(NMDA)receptor channel LTP |
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| TIAN Wen-juan,TIAN Xin.Voltage-dependent calcium channel(VDCC)LTP and N-methyl-D-aspartate(NMDA)receptor channel LTP[J].International Journal of Biomedical Engineering,2008,31(2). |
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| Authors: | TIAN Wen-juan TIAN Xin |
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| Abstract: | Long-term potentiation(LTP)is a typical model of synaptic plasticity which has great relationship with learning and memory mechanisms:The induction of LTP depends on the activation of the calcium channels and LTPs generated by calcium ions influx through different channels play different roles in memory.This paper reviews the progress of the research on LTPs induced by activations of N-methyl-D-aspanate receptor(NMDAR)channels and voltage-dependent calcium channels(VDCC).Finally,it gives an example of new forms of low frequency stimulation for induction of LTP. |
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| Keywords: | Long-term potentiation Memory N-methyl-D-aspartate receptor channel Voltagedependent calcium channel Low frequency stimulation |
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