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| 食管癌组织中Ebp1基因的表达及意义 | |
| 引用本文： | 崔玲玲,胡同宇,朱明宇,陈幕华,陈萍萍,谢东,李文杰.食管癌组织中Ebp1基因的表达及意义[J].肿瘤防治研究,2011,38(1):48-50. |
| 作者姓名： | 崔玲玲 胡同宇 朱明宇 陈幕华 陈萍萍 谢东 李文杰 |
| 作者单位： | 1. 郑州大学公共卫生学院,郑州,450001 2. 卫生部妇幼保健与社区卫生司 3. 开封市疾病控制中心 |
| 基金项目： | 国家自然科学基金资助项目(30725010) |
| 摘 要： | 目的 研究人食管癌组织中Ebp1 mRNA表达水平及其与临床参数的关系。方法 采用实时荧光定量PCR对220例食管癌组织和癌旁正常食管组织中Ebp1 mRNA表达水平进行测定。结果 150（68.18%）例食管癌样本中Ebp1 mRNA表达上调，单因素分析显示，与Ebp1 mRNA表达高度相关的临床参数包括年龄、家族史、淋巴结转移、肿瘤体积、分化程度、浸润深度和临床分期。而性别、病理类型和肿瘤位置与Ebp1 mRNA的表达无关。多因素分析结果表明：家族史、肿瘤体积、分化程度、浸润深度和临床分期均是Ebp1 mRNA表达的危险因素，而病理类型是Ebp1 mRNA表达的保护因素，髓质型的Ebp1 mRNA表达比溃疡型和蕈伞型高。结论 Ebp1在食管癌发展过程中起重要作用，可能作为食管癌病情进展的监测、转移潜能及预后评估方面的一个靶基因。 |
| 关 键 词： | Ebp1 食管癌 实时荧光定量PCR |
| 收稿时间： | 2009-10-15; |
Expression and Significance of Ebp1 Gene in Human Esophageal Cancer Tissues |
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| CUI Ling-ling,HU Tong-yu,ZHU Ming-yu,CHEN Mu-hua,CHEN Ping-ping,XIE Dong,LI Wen-jie.Expression and Significance of Ebp1 Gene in Human Esophageal Cancer Tissues[J].Cancer Research on Prevention and Treatment,2011,38(1):48-50. | |
| Authors: | CUI Ling-ling HU Tong-yu ZHU Ming-yu CHEN Mu-hua CHEN Ping-ping XIE Dong LI Wen-jie |
| Affiliation: | CUI Ling-ling1,HU Tong-yu2,ZHU Ming-yu1,CHEN Mu-hua3,CHEN Ping-ping1,XIE Dong1,LI Wen-jie11.College of Public Health,Zhengzhou University,Zhengzhou 450001,China,2.Department of Maternal and Child Health Care and Community Health,3.Kaifeng Municipal Centers for Disease Control |
| Abstract: | Objective To study mRNA expression levels of Ebp1 and their relations to clinical and pathological features in human esophageal cancer.Methods Ebp1 expression levels were quantified by real-time PCR assay from two hundred and twenty esophageal cancer tissues and from their matched adjacent normal esophageal tissues.Results One hundred and fifty(68.18%)samples were found up-regulation of Ebp1 in esophageal cancer comparing to the matched normal esophageal tissues.Univariate analysis showed that the Ebp1 mRNA... |
| Keywords: | Ebp1 Esophageal cancer Real-time PCR |
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