不典型慢性粒细胞白血病血液学特征分析

目的：探讨不典型慢性粒细胞白血病的诊断．方法：对比分析12例不典型慢性粒细胞白血病和23例典型慢性粒细胞白血病的临床表现和血液细胞学特征．结果：不典型慢性粒细胞白血病发病年龄较大，多数患者元贫血，血小板轻度增高，脾大不明显，外周血中性粒细胞碱性磷酸酶积分稍减低或正常，Ph染色体阴性，PCR检测阴性．结论：不典型慢性粒细胞白血病诊断必须结合临床动态观察，若随病程延长，病情加重，其他治疗无效者，应考虑本病．

The Analysis of Atypical Chronic Myelogenous Leukemia

Objective: To investigate the diagnosis of atypical chronic myelogenous leukemia.Methods: Through the comparison between atypical chronic myelogenous leukemia (12 cases) and typical chronic myelogenous leukemia (23 cases), we can find out that atypical chronic myelogenous leukemia was different from typical chronic myelogenous leukemia in clinical characteristics and morphology features.Results:First of all,the patients' age is always old.In most cases, there was not anemia but platelet was slightly higher than the normal, swelling of spleen was not unconspicuous, and the neutrophil alkaline phosphatase score was normal or slightly decreased.Philadelphia (Ph) chromosome was undetectable by polymerase chain reaction (PCR) as well.Conclusion: To diagnose this disease, the course of disease must be observed in succession which is aggravated along with the time passing and the other therapies are invalid.