早产儿霉菌感染分析

Objective To stuay the features of fungal infection by analyzing the preterm inpatient in our departrment retrospectively.Methods All preterm(1716 babies)inpatient in our department were ealtrolled between April 2005 to January 2008,and the assessment ofinfection was taken by elinical symptom and laratory examillation.The infected babies were give.flueonazol 6mg/(kg·d)by intravenous drip,and amphoteriein B and ganmla globulin would be used for those babies who were still sick.Results A total of 11 cases were diagnod as fungus infection.and another 26 cases of suspected fungus infecdon for a total of37 cases.accounting forthe total number of premature infants 2.16 percents;the death ofthree cases Qfinfection case-fatality rate was 8.1%.The average gestational age was(30.7±2.3)weeks,and 31 cases were less than 32 weeks,aceoundng or 83.78%.The average age ofinfecdon was(19.21±8.02)days;All babies were given two ormoire anubiodes,and used in part ortotal parenteral nutrition,and the number of babies had been conducted with invasive operation was 29.accounting for 78.38%.Conclusion Applicadon of a wide range of broad-spectnlm antibiotie,combined with a variety of antiNodes,invasive treatment in premature infants are nosoeomial fungal infection of the main faetors,the smaller gestational age,the more possibility fungal infoetion.Fluconazole is effective for fungal infection of newborns,and can be comidered as first.line drug.For premature infants,the longer-term(14 days or above)use of antifungal agents may be more appropriate treatment cycle.

Fungal infection in premature