| ^3H—SC1001的吸收,分布和排泄 |
| |
| 引用本文： | 张祖谦,雷幼导.^3H—SC1001的吸收,分布和排泄[J].华西医科大学学报,1989,20(1):35-38. |
| |
| 作者姓名： | 张祖谦 雷幼导 |
| |
| 摘 要： |
|
| 关 键 词： | ^3HSC1001 吸收 分布 排泄 |
Absorption, distribution and excretion of 3H-SC1001 |
| |
| Z Q Zhang,Z J Ma,B X Sun,Y D Lei,Q A Zhou.Absorption, distribution and excretion of 3H-SC1001[J].Journal of West China University of Medical Sciences,1989,20(1):35-38. |
| |
| Authors: | Z Q Zhang Z J Ma B X Sun Y D Lei Q A Zhou |
| |
| Abstract: | SC1001 is a new Synthesized CNS depressant. In this paper, the absorption, distribution and excretion of 3H-SC1001 in mouse and rats were studied by radioactivity trace method. The experiment showed that SC1001 was absorbed rapidly after administering orally and intramuscularly. Maximum radioactivity was found at 0.13h and 0.33h. The rapidly and widely distribution was demonstrated after absorption, the level of radioactivity was the highest in the blood, then in liver, kidney, intestine lung, heart, spleen, and brain. 3H-SC1001 could easily pass through the blood-brain barrier. 3H-SC1001 was eliminated in faeces and then in urine. In 3 days the cumulative radioactivity excretion was 32.0% in urine and 74.04% in faeces, t1/2 of p.o. was 5.69h and t1/2 of i.m. was 6.91h. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
