Optimizing light delivery in scanning photoacoustic imaging for prostate |
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| Authors: | PENG Dong-qing LIU Zhi-gao XU Hui-zhen ZHU Li-li and LI Hui |
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| Affiliation: | School of Science, Jimei University, Xiamen 361021, China,School of Science, Jimei University, Xiamen 361021, China,School of Science, Jimei University, Xiamen 361021, China,Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education of China, Fujian Provincial Key Laboratory of Photonic Technology, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China and Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education of China, Fujian Provincial Key Laboratory of Photonic Technology, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China |
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| Abstract: | The purpose of this study was to optimize the light delivery method in a prostate photoacoustic imaging system. A three dimensional (3D) optical model of the human prostate was developed, and the optical energy distribution in the prostate was estimated via three-dimensional Monte Carlo simulation. Then, the feasibility of prostate photoacoustic imaging (PAI) using two endoscopic light delivery methods was studied. Photoacoustic pressure generation and the corresponding photoacoustic images had been obtained and the comparisons were made between each other. Also, the results of cylinder diffusing light source with different lengths were compared. After that, phantom experiment was carried out to validate the simulation results. Our results would be significant in the optimizing photoacoustic imaging system for an accurate diagnosis of prostate cancer. |
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