| 青蒿中1个新的生物碱类化合物 |
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| 引用本文： | 李海波,黄玉欣,秦大鹏,曹亮,王振中,姚新生,于洋.青蒿中1个新的生物碱类化合物[J].中草药,2021,52(2):327-330. |
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| 作者姓名： | 李海波 黄玉欣 秦大鹏 曹亮 王振中 姚新生 于洋 |
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| 作者单位： | 暨南大学中药及天然药物研究所, 广东 广州 510632;江苏康缘药业股份有限公司, 中药制药过程新技术国家重点实验室, 江苏 连云港 222001;深圳大学医学部药学院, 广东 深圳 518060 |
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| 基金项目： | 重大新药创制科技重大专项“十三五”计划（2018ZX09711001-008-005）；国家自然科学基金重点项目（81630097） |
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| 摘 要： | 目的研究青蒿(黄花蒿Artemisia annua)干燥地上部分的化学成分。方法综合应用HP-20、硅胶、ODS、Sephadex LH-20和半制备液相等多种色谱学方法进行分离纯化,并根据化合物的理化性质和核磁共振波谱数据进行结构鉴定。结果从青蒿干燥地上部分水提取物中分离得到了5个化合物,分别鉴定为(S)-2,6,11-trimethyl-7,8-dihydro-6H-cycloheptab]pyridine-9-carboxylic acid(1)、arteannoide E(2)、蚱蜢酮(3)、(6S,9S)-长寿花糖苷(4)、artemanin B(5)。结论化合物1为新的生物碱,命名为青蒿生物碱;化合物3为首次从蒿属植物中分离得到。
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| 关 键 词： | 青蒿 生物碱 (S)-2 6 11-trimethyl-7 8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid 青蒿生物碱 蚱蜢酮 (6S 9S)-长寿花糖苷 |
| 收稿时间： | 2020/9/15 0:00:00 |
A new alkaloid from Artemisia annua |
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| LI Hai-bo,HUANG Yu-xin,QIN Da-peng,CAO Liang,WANG Zhen-zhong,YAO Xin-sheng,YU Yang.A new alkaloid from Artemisia annua[J].Chinese Traditional and Herbal Drugs,2021,52(2):327-330. |
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| Authors: | LI Hai-bo HUANG Yu-xin QIN Da-peng CAO Liang WANG Zhen-zhong YAO Xin-sheng YU Yang |
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| Affiliation: | Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China |
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| Abstract: | Objective To study the constituents from the dried aboveground part of Artemisia annua. Methods The compounds were isolated and purified by column chromatography of HP-20 macroporous resin, silica gel, ODS, Sephadex LH-20, and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results Five compounds were isolated and identified from the water extract of A. annua, including alkaloid; (S)-2,6,11-trimethyl-7,8- dihydro-6H-cycloheptab]pyridine-9-carboxylic acid (1), arteannoide E (2), grasshopper ketone (3), (6S,9S)-roseoside (4) andartemanin B (5). Conclusion Compound 1 is a new alkaloid named arteannine. Compound 3 is identified from Artemisia genus for the first time. |
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| Keywords: | Artemisia annua L alkaloid (S)-2 6 11-trimethyl-7 8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid arteannine grasshopper ketone (6S 9S)-roseoside |
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