| 6-巯基嘌呤的合成新方法研究 |
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| 引用本文： | 王云龙,李永曙,谭成侠.6-巯基嘌呤的合成新方法研究[J].精细化工中间体,2013,43(3):23-25. |
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| 作者姓名： | 王云龙 李永曙 谭成侠 |
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| 作者单位： | 浙江工业大学药学院,浙江杭州,310014 |
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| 摘 要： | 以乙醇、二硫化碳和氢氧化钾为原料制得乙基黄原酸钾,乙基黄原酸钾再与6-氯嘌呤经取代,经水解制得6-巯基嘌呤。考察了乙基黄原酸钾和水的用量、温度和时间对反应的影响。优化后的工艺条件为:m(6-氯嘌呤)∶m(水)=1∶15,n(6-氯嘌呤)∶n(乙基黄原酸钾)=1∶1.05。收率为93.4%。该方法避免了有机溶剂及严重污染环境的五硫化二磷的使用,反应步骤少、操作简单,适于工业化生产。
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| 关 键 词： | 6-氯嘌呤 乙基黄原酸钾 水解 6-巯基嘌呤 |
Novel Synthesis of 6-Mercaptopurine |
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| WANG Yun-long,LI Yong-shu,TAN Cheng-xia.Novel Synthesis of 6-Mercaptopurine[J].Fine Chemical Intermediates,2013,43(3):23-25. |
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| Authors: | WANG Yun-long LI Yong-shu TAN Cheng-xia |
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| Affiliation: | *(College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | 6-Mercaptopurine was obtained in 93.4% yield by hydrolysis of the reaction product of 6-chloropurine and potassium ethyl xanthate,which was prepared from ethanol,carbon disulfide and potassium hydroxide..The affective factors of the molar ratio of the reactants,the reaction temperature and the time were investigated.The optimized conditions were as follows： n（6-chloropurine）∶n（potassium ethyl xanthate）=1∶1.05,m（6-chloropurine） ∶m（water）=1∶15.The organic solvents and phosphorus pentasulfide have been avoided with simple operation and workup. |
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| Keywords: | 6-chloropurine potassium ethyl xanthate hydrolysis 6-mercaptopurine |
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