Innate immunity to Paracoccidioides brasiliensis infection |
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Authors: | Vera Lúcia Garcia Calich Tânia Alves da Costa Maíra Felonato Celina Arruda Simone Bernardino Flávio Vieira Loures Laura Raquel Rios Ribeiro Rita de Cássia Valente-Ferreira Adriana Pina |
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Affiliation: | 1. Departamento de Imunologia, Instituto de Ciências Biomédicas da Universidade de S?o Paulo (USP), Av. Prof. Lineu Prestes 1730, CEP 05508-900, Sao Paulo, SP, Brazil
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Abstract: | Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading
to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial
pathogen growth and have profound effect on the adaptative immune response that further develops. Although most studies in
paracoccidioidomycosis have been dedicated to understand cellular and humoral immune responses, innate immunity remains poorly
defined. Hence, the main purpose of this review is to present and discuss some mechanisms of innate immunity developed by
resistant and susceptible mice to Paracoccidioides brasiliensis infection, trying to understand how this initial host-pathogen interface interferes with the protective or deleterious adaptative
immune response that will dictate disease outcome. An analysis of some mechanisms and mediators of innate immunity such as
the activation of complement proteins, the microbicidal activity of natural killer cells and phagocytes, the production of
inflammatory eicosanoids, cytokines, and chemokines among others, is presented trying to show the important role played by
innate immunity in the host response to P. brasiliensis infection. |
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Keywords: | Cytokines Dendritic cells Innate immunity Macrophages NK and PMN Cells Paracoccidioides brasiliensis infection |
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