Synthesis and antileishmanial activity of alpha-cyano ethyl propenoates--a new class of antileishmanials |
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| Authors: | Tiwari S Gupta S Tripathi R P Khan A R Katiyar J C Bhaduri A P |
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| Affiliation: | Division of Parasitology, Central Drug Research Institute, Lucknow, India. |
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| Abstract: | A number of alpha-cyano-beta-substituted ethyl propenoates were synthesised by condensation of appropriate aldehydes with ethyl cyanoacetate in basic medium. These compounds have been studied for their antileishmanial activities in vivo in hamsters. Two compounds exhibited 70-77% activities both by intramuscular and oral routes. |
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