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| 不饱和脂肪酸逆转乳腺癌细胞株耐药性研究 | |
| 引用本文： | 刘冰冰,梁仁,杨世杰.不饱和脂肪酸逆转乳腺癌细胞株耐药性研究[J].吉林医药学院学报,2001,23(2):67-69. |
| 作者姓名： | 刘冰冰 梁仁 杨世杰 |
| 作者单位： | 1. 吉林军医学院药理学教研室, 2. 广东药学院, 3. 吉林大学药学院, |
| 摘 要： | 目的 探讨不饱和脂肪酸二十二碳六烯酸 (DHA)是否能够逆转人乳腺癌细胞的多药耐药性(MDR)。方法 采用MTT法对DHA和阿霉素合用时肿瘤细胞的半数抑制率 (IC50 )进行检测。结果 DHA(10 μg/ml)组能提高MCF 7/R细胞株对阿霉素敏感性 3.2倍 ,DHA(2 0 μg/ml)组提高 5 .1倍 ,均有非常显著性差异 (P <0 .0 1)。结论 DHA能部分逆转乳腺癌耐药细胞对阿霉素的耐药性 |
| 关 键 词： | 不饱和脂肪酸 阿霉素 乳腺癌 多药耐药性 |
| 文章编号： | 1009-8488(2001)02-0067-03 |
| 修稿时间： | 2001年3月7日 |
Effect of Unsaturated Fatty Acid on Reversing Drug-resistance of Breast Cancer Cell Strain |
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| LIU Bing-bing,Liang Ren,YANG Shi-jie.Effect of Unsaturated Fatty Acid on Reversing Drug-resistance of Breast Cancer Cell Strain[J].Journal of Jilin Medical College,2001,23(2):67-69. | |
| Authors: | LIU Bing-bing Liang Ren YANG Shi-jie |
| Affiliation: | LIU Bing Bing 1,LIANG Ren 2,YANG Shi Jie 3 |
| Abstract: | Objective To explore whether docosahexaenoic acid(DHA)might reverse multidrug resistance of breast cancer cells.Methods IC50 in cancer cells was examined through MTT method while DHA was used in combination with adrimycin.Results In DHA (10 μg/ml)group,the sensitivity of MCF-7/R cell strain to adrimycin was increased by 320 % while 510 % in DHA(20 μg/ml) group and there were great differences (P＜0.01).Conclusion DHA can partly reverse the drug resistance of breast cancer cells to adrimycin. |
| Keywords: | unsaturated fatty acid adrimycin breast cancer multidrug resistance |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
