阿昔洛韦明胶微球的制备及体外释放度考察

目的:制备阿昔洛韦明胶微球,并考察其体外释放性能。方法:采用乳化交联法制备阿昔洛韦明胶微球,通过考察其粒径、包封率、载药量优化处方工艺。结果:该工艺制备的微球光滑圆整,其平均粒径为21μm,粒径分布均匀。载药量、包封率分别为15.3%、80.5%。12min体外累积释药量达95.2%。结论:采用乳化交联法制备的明胶微球具有很好的缓释效果。

Study on Preparation and Release Behavior of Aciclovir Microspheres

Objective：Study on Preparation and Release Behavior of aciclovir Microspheres.Methods：The way of emulsion cross-linked was used to prepare microspheres of acyclovir and the size,encapsulation efficiency,drug loading formulation and process optimization were examined,respectively.Results：Result：Microspheres prepared by the process were smooth and round,the average particle size was 21μm,with narrow size distribution.Drug loading,encapsulation efficiency was 15.3%,80.5%,respectively.The cumulative release in vitro on 12h reached 95.2%.Conclusion：The gelatin microspheres prepared by emulsion cross-linked were with good slow-release effect.