DNA修复基因XRCC1 Arg194Trp Arg280His和Arg399Gln多态性与前列腺癌相关性的Meta分析

目的探讨DNA修复基因X线修复交叉互补因子1（XRCC1）主要单核苷酸多态性与前列腺癌易感性的关系。方法在MEDLINE、EMBASE和OVID数据库上检索文献,收集及提取符合纳入标准的以XRCC1密码子194、280、399多态性与前列腺癌易感性为内容的病例对照研究文献,应用Stata统计软件进行Meta分析,比值比（ORs）及其95%可信区间（95%CI）评价关联强度;应用SPSS软件分析吸烟与前列腺癌关系,OR？评价其相对危险度。结果 XRCC1 399 Gln/Gln和XRCC1 280 Arg/His与前列腺癌的发病风险有关（Gln/Gln vs Arg/Arg：OR？=1.27,95%CI=1.02～1.59;Arg/His vs Arg/Arg：OR？=1.66,95%CI=1.09～2.52）,尤其在亚组分析中亚洲人的Gln/Gln明显增加了前列腺癌的发病风险（OR？=1.52,95%CI=1.18～1.96）;Arg194Trp与前列腺癌的发病风险无明显关联。吸烟是前列腺癌的危险因素（χ2=13.974,P=0.000,OR？=1.22）。结论 XRCC1 399 Gln/Gln和280 Arg/His可能与前列腺癌的易感性相关。

XRCC1 Arg194Trp, Arg280His, Arg399Gln polymorphisms and prostate cancer risk: a Meta-analysis

Objective To evaluation the relationship between X-ray repair cross-complementing group 1（XRCC1） single nucleotide polymorphisms（SNPs） and genetic susceptibility to prostate cancer（Pca） risk.Methods We searched on MEDLINE,EMBASE and OVID,collected and abstracted the case-control studies about XRCC1 codon 194,280,399 polymorphisms and genetic susceptibility of Pca;did Meta-analysis by Stata,Odds ratios（ORs） and 95% confidence interval（95% CI） were calculated to evaluate correlation strength;the relation between smoking and Pca was analyzed by SPSS,OR？ evaluated relative risk of smoking.Results XRCC1 399 Gln / Gln and XRCC1 280 Arg / His were related with risk for Pca（Gln / Gln vs Arg / Arg： OR= 1.27,95% CI = 1.02～1.59;Arg / His vs Arg / Arg： OR= 1.66,95% CI = 1.09～2.52）,especially Asian Gln / Gln obviously increased risk for Pca（OR= 1.52,95% CI = 1.18～1.96）;Arg194Trp was not related with risk for Pca.Smoking was a risk factor of Pca（χ2= 13.974,P = 0.000,OR= 1.22）.Conclusion XRCC1 399 Gln / Gln and XRCC1 280 Arg / His were probably related with genetic susceptibility to Pca.