高胆红素血症对新生儿红细胞免疫功能的影响 |
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引用本文: | 顾岚,宋国英,张洁,李军,马岩. 高胆红素血症对新生儿红细胞免疫功能的影响[J]. 江苏医药, 2012, 38(14): 1657-1659 |
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作者姓名: | 顾岚 宋国英 张洁 李军 马岩 |
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作者单位: | 顾岚 (南通大学附属吴江市第一人民医院新生儿科,江苏省,215200) ; 宋国英 (南通大学附属吴江市第一人民医院新生儿科,江苏省,215200) ; 张洁 (南通大学附属吴江市第一人民医院新生儿科,江苏省,215200) ; 李军 (南通大学附属吴江市第一人民医院新生儿科,江苏省,215200) ; 马岩 (南通大学附属吴江市第一人民医院新生儿科,江苏省,215200) ; |
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基金项目: | 南通大学校级自然科学类科研基金,软件学研究项目,吴江市2010年社会发展计划 |
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摘 要: | 目的探讨高胆红素血症新生儿红细胞免疫黏附功能的变化。方法 115例高胆红素血症新生儿,按血清总胆红素(TSB)水平分为两组:A组81例,TSB 220.6-342.0μmol/L;B组34例,TSB>342.0μmol/L。50例TSB正常新生儿作为对照(C)组。分别在入院和出院时应用红细胞C3b受体花环率(RCR)评估红细胞天然免疫黏附功能。结果 B组新生儿的红细胞RCR明显低于C组[(9.15±2.98)%vs.(11.12±3.53)%)](P<0.05)。B组红细胞天然免疫黏附功能与TSB值呈负相关(r=-0.362,P<0.05)。结论高胆红素血症新生儿的红细胞免疫黏附功能下降。
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关 键 词: | 高胆红素血症 红细胞免疫黏附功能 新生儿 |
Effect of hyperbilirubinemia on erythrocyte immune function in neonates |
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Affiliation: | GU Lan,SONG Guoying,ZHANG Jie,et al.Department of Neonatology,Affiliated First People’s Hospital of Wujiang,Nantong University,Wujiang 215200,CHINA |
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Abstract: | Objective To investigate the effect of hyperbilirubinemia on erythrocyte immune function in neonates.Methods A total of 115 neonates with hyperbilirubinemia was assgined to two groups of A[81 cases with total serum bilirubin(TSB) 220.6-342.0 mol/L] and B(34 cases with TSB>342.0 mol/L).Another 50 healthy neonates were taken as the controls(group C).The natural immune-adhesion function of erythrocyte was evaluated with red blood cell C 3b receptor rosette rate(RCR) at admission and discharge.Results RCR of erythrocyte was lower in group B than that in group C[(9.15±2.98)% vs.(11.12±3.53)%)](P<0.05),which was negatively correlated to TSB(r=-0.362,P<0.05).Conclusion The natural immune-adhesion function of erythrocyte is decreased in the neonates with hyperbilirubinemia. |
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Keywords: | Hyperbilirubinemia Erythrocyte immune-adhesion function Neonates |
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