| 3-(N-乙基-N-甲氧基羰基甲基)氨基-4-甲氧基乙酰苯胺的合成工艺研究 |
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| 引用本文： | 刘艳营,李坤兰,王茜萌.3-(N-乙基-N-甲氧基羰基甲基)氨基-4-甲氧基乙酰苯胺的合成工艺研究[J].精细石油化工,2010,27(6). |
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| 作者姓名： | 刘艳营 李坤兰 王茜萌 |
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| 基金项目： | 教育部科学技术重点资助项目，大连市科技计划项目 |
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| 摘 要： | 以3-(N-乙基)氨基-4-甲氧基乙酰苯胺(Ⅰ)和氯乙酸甲酯为原料、无水碳酸钠为缚酸剂、甲苯为溶剂,合成3-(N-乙基-N-甲氧基羰基甲基)氨基-4-甲氧基乙酰苯胺。经正交实验法,考察了Ⅰ和氯乙酸甲酯的摩尔投料比、反应温度、甲苯及碳酸钠用量对收率的影响,其最佳工艺条件为:n(Ⅰ):n(氯乙酸酯)=1:1.1,反应温度为100℃,溶剂甲苯用量为10.4 mL,n(Ⅰ):n(碳酸钠)=1:0.56,收率96.8%。
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| 关 键 词： | 3-(N-乙基)氨基-4-甲氧基乙酰苯胺 3-(N-乙基-N-甲氧基羰基甲基)氨基-4-甲氧基乙酰苯胺 氯乙酸甲酯 |
PROCESS FOR SYNTHESIS OF 3-(N-ETHYL-N-METHOXYLONEMETHYL)AMINO-4-METHYL ACCETANILIDE |
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| Liu Yanying,Li Kunlan,Wang Ximeng.PROCESS FOR SYNTHESIS OF 3-(N-ETHYL-N-METHOXYLONEMETHYL)AMINO-4-METHYL ACCETANILIDE[J].Speciality Petrochemicals,2010,27(6). |
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| Authors: | Liu Yanying Li Kunlan Wang Ximeng |
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| Abstract: | 3-(N-ethyl-iV-methoxylonemethyl) amino-4-methyl accetanilide was synthesized from 3-(N- ethyl) amino-4-methoxy acetanilide (Ⅰ) and methyl chloroacetate,using anhydrous sodium carbonate as an acid binding agent and toluene as solvent.The optimum reaction conditions were obtained by orthogonally arranged experiments as follows: molar ratio of Ⅰ to methyl chloroacetate 1:1.1,reaction temperature 100℃ ,solvent 10.4 mL and molar ratio of Ⅰ to sodium carbonate 1:0.56.Under these conditions,the yield of 3-(N-ethyl-N-methoxylonemethyl) amino-4-methyl accetanihde was 96.8% with purity of 96.1% by HPLC. |
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| Keywords: | 3-(N-ethyl) amino-4-methoxy acetanilide 3-(N-ethyl-N-methoxyloneme-thyl) amino-4-methyl accetanilide methyl chloroacetate |
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