Predicting the carcinogenicity of the aromatic amine derivatives tested in the second UKEMS collaborative study

The carcinogenicity prediction and battery selection (CPBS)procedure was used to analyze the short-term in vitro and invivo genotoxicity results obtained during the Second UKEMS CollaborativeStudy. In accordance with preliminary animal bioassay results,CPBS predicted correctly the carcinogenicity of benzidine, 4,4'-diaminoterphenyland 4-dimethylaminoazobenzene. CPBS predicted the non-carcino-genkityof 4-cyanodimethylaniline, a chemical of as yet unknown carcinogenicity.Moreover, CPBS indicated that for the chemicals included inthe UKEMS study, highly predictive as well as cost-effectivebatteries consisting of three short-term assays could be identified.