| 微小RNA在力相关牙周炎症反应和组织改建中的作用 |
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| 引用本文： | 宋迎爽,胥春.微小RNA在力相关牙周炎症反应和组织改建中的作用[J].医用生物力学,2021,36(1):164-168. |
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| 作者姓名： | 宋迎爽 胥春 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院/口腔医学院 口腔修复科; 国家口腔疾病临床医学研究中心;上海市口腔医学重点实验室/上海市口腔医学研究所 |
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| 基金项目： | 国家自然科学基金项目（31470903，31270991，30900282），上海市浦江人才计划项目（13PJD021），上海市青年科技启明星计划（A类）项目（10QA1404200） |
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| 摘 要： | 微小核糖核酸(micro-ribonucleic acid,miRNA)是一种非编码单链RNA分子,可通过抑制靶基因mRNA的翻译来调控生物体遗传信息表达,参与体内多种生物学过程的发生发展.miRNA在机械力诱导机体产生的炎症性疾病和组织改建中发挥着重要作用.牙周组织中机械力敏感细胞可在力作用下导致牙周组织炎症反应、组...
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| 关 键 词： | 微小核糖核酸 机械力 牙周组织 炎症 组织改建 |
| 收稿时间： | 2020/4/24 0:00:00 |
| 修稿时间： | 2020/5/5 0:00:00 |
The Role of MicroRNA in Force-Related Periodontal Inflammatory Response and Tissue Remodeling |
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| SONG Yingshuang,XU Chun.The Role of MicroRNA in Force-Related Periodontal Inflammatory Response and Tissue Remodeling[J].Journal of Medical Biomechanics,2021,36(1):164-168. |
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| Authors: | SONG Yingshuang XU Chun |
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| Affiliation: | (Department of Prosthodontics,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;National Clinical Research Center for Oral Diseases,Shanghai 200011,China;Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China) |
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| Abstract: | Micro-ribonucleic acid(miRNA) is a kind of non-coding single-stranded RNA, which can regulate the expression of genetic information by inhibiting mRNA translation of the target gene and participate in the occurrence and development of a variety of biological processes in vivo. miRNAs also take part in inflammatory diseases and tissue remodeling induced by mechanical forces. Mechanosensitive cells in periodontal tissue can lead to pathological/physiological changes such as periodontal inflammatory response and periodontal remodeling. miRNAs might have played important roles in the occurrence and development of force-related periodontal inflammatory diseases and tissue remodeling, by inhibiting the translation of specific genes in these cells. This article reviews the roles of miRNAs in force-related inflammatory response and tissue remodeling, especially in periodontal inflammatory response and tissue remodeling. |
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| Keywords: | micro-ribonucleic acid(miRNA) mechanical force periodontium inflammation tissue remodeling |
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