| 烧伤与脂质过氧化损伤 |
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| 引用本文： | 吴文安,周玫,齐凤菊,郝廷智,周伟明,陈瑗,孔华.烧伤与脂质过氧化损伤[J].南方医科大学学报,1987(Z1). |
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| 作者姓名： | 吴文安 周玫 齐凤菊 郝廷智 周伟明 陈瑗 孔华 |
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| 作者单位： | 广东省武装警察总队中心医院烧伤科
(吴文安)，第一军医大学生物化学教研室
(周玫，齐凤菊)，第一军医大学第一附属医院烧伤科
(郝廷智，周伟明)，第一军医大学医学防护教研室
(陈瑗)，第一军医大学医学防护教研室(孔华) |
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| 摘 要： | 本文观察了烧伤患者15天内血浆和RBC的脂质过氧化速率,VE含量和硒谷胱甘肽过氧酶SeGSHPx活性的变化.结果表明血浆脂质过氧化物LPO含量增加,VE含量和SeGSHPx活性降低,以伤后10天为最显著:RBC的自发性溶血百分率和SeGSHPx活性增加,RBC VE含量降低。血浆和RBC的脂质过氧化速率增加和它们的VE含量降低的变化规律相一致。血浆LPO和VE含量以及SeGSHPx活性变化幅度与烧伤严重度相关。
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| 关 键 词： | 烧伤 脂质 过氧化 脂质过氧化物 红细胞 溶血 维生素E 硒谷胱甘肽过氧酶 |
Relation of lipoperoxidation damage to burn |
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| Wu Wenan,et al.Relation of lipoperoxidation damage to burn[J].Journal of Southern Medical University,1987(Z1). |
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| Authors: | Wu Wenan |
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| Affiliation: | The First Medical College of PLA |
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| Abstract: | In this study the plasma and erythrocyte ( RBC ) lipoperoxidation rate, the content of the antioxidant vitamin E ( VE ) and the activity of the antioxi-dation enzyme selenium dependent glutathione peroxidase ( SeGSHPx ) of plasma and RBC in burn patients were determined on the 1st, 3rd, 5th, 10th and 15th days after burn. The results showed that compared to healthy subjects, the con- tent of lipoperoxide was increased and the level of VE and the activity of SeGSHPx were decreased significantly in the plasma, and the most significant changes were on the 10th day post-burn. In the meantime the percentage of RBC spontaneous hemolysis and the activity of SeGSHPx in RBC were increased and the content of VE in RBC were decreased markedly. The regularity of the changes in lipoperoxidation rate of plasma and RBC was in accordance with that in the contents of VE in them.The degrees of the changes in the LPO and VE content and the SeGSHPx activity in plasma were in relation to the extent of burn. |
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| Keywords: | burn lipoperoxidation rate lipoperoxide erythrocytehemolysis vitamin E selenium dependent glutathioneperoxidase |
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